Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre‐eclampsia

Please cite this paper as: Shand A, Nassar N, Von Dadelszen P, Innis S, Green T. Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre‐eclampsia. BJOG 2010;117:1593–1598. Objective To determine in a group of pregnant women if vitamin D status, based on serum 25‐hydroxyvitamin D (25OHD) concentration, was associated with a subsequent risk of pre‐eclampsia or adverse pregnancy outcomes. Design Prospective cohort study. Setting Vancouver, British Columbia, Canada (49°N). Population Women attending a specialist antenatal clinic because of clinical or biochemical risk factors for pre‐eclampsia (n = 221). Methods Serum 25OHD concentration measured between 10 and 20 weeks of gestation. Main outcome measures Pre‐eclampsia and composite adverse pregnancy outcomes. Results Of the women, 78% were vitamin D insufficient (25OHD