Adult respiratory distress syndrome: Roles of leukotriene C4 and platelet activating factor

The relationship between leukotriene C4 (LTC4), activating factor (PAF), and adult respiratory syndrome (ARDS) was studied in nine patients 84 control subjects. A leukocyte adherence (LAI) assay induced by each of the ligands was to monitor the subjects for 3 consecutive days or clinical recovery was noted. LAI was considered positive if the nonadherence index (NAI) was >30 LTC4 or >20 for PAF. LAI was negative in all subjects using both ligands. LTC4-induced LAI positive in all nine ARDS patients and reverted to after recovery from the syndrome, while three 3%) of nine patients responded to PAF. In contrast, 84 control subjects, LAI was induced by LTC4 in three (3.3%) and by PAF in five (5.9%). The mean (52.2 ± 18) of LTC4-induced LAI in ARDS was significantly (p < .05) higher when compared the control group (-5 ± 6.4), whereas that of PAF-LAI was