A new class of cis-monobactam derivatives bearing a sulfamoyloxymethyl or an N-alkylsulfamoyloxymethyl group at position 4: Synthesis and antibacterial activity
A new series of monobactam derivatives, bearing unsubstituted or N-monosubstituted sulfamoyloxymethyl groups in position 4 was synthesized either in racemic or in optically active form. Their in vitro antibacterial activity was tested in comparison with carumonam 1a and its methoxyimino derivative 1...
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| Veröffentlicht in: | Farmaco (Società chimica italiana : 1989) 1998-03, Vol.53 (3), p.173-180 |
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| container_end_page | 180 |
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| container_issue | 3 |
| container_start_page | 173 |
| container_title | Farmaco (Società chimica italiana : 1989) |
| container_volume | 53 |
| creator | Guanti, Giuseppe Riva, Renata Cascio, Giuseppe Manghisi, Elso Morandotti, Grazia Satta, Giuseppe Sperning, Roberta |
| description | A new series of monobactam derivatives, bearing unsubstituted or N-monosubstituted sulfamoyloxymethyl groups in position 4 was synthesized either in racemic or in optically active form. Their in vitro antibacterial activity was tested in comparison with carumonam
1a and its methoxyimino derivative
1b. |
| doi_str_mv | 10.1016/S0014-827X(98)00004-4 |
| format | Article |
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Drug treatments</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Sulfur Compounds - chemical synthesis</subject><subject>Sulfur Compounds - pharmacology</subject><subject>β-Lactams</subject><issn>0014-827X</issn><issn>1879-0569</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdFqFDEUhoModa0-QiEXInoxmslkMok3UopVoehFFbwLZzJn2mhmsibZ1XkbH7XZ7rJXgoGQhP_7zwnnJ-SsZq9rVss314zVolK8-_5Sq1esLFGJB2RVq05XrJX6IVkdkcfkSUo_yrPrZHdCTrRstJLtivw9pzP-ptZDSjSM1LpUTWEOPdgMEx0wui1kt8VEe4To5hsKNG38CFNYfPizTJhvF09DpDDTzxX4n4v_h34Tw2ZNIdN1SC67MFPxll4vc77F5FLxDmVnt2tbWoKn5eK2Li9PyaMRfMJnh_OUfLt8__XiY3X15cOni_OryjZK54pLKxqOxd_2bTv2vR1VbVFyrWuhYNSjkAyaVvWWMya5ksMAne5bWyPyljWn5MW-7jqGXxtM2UwuWfQeZgybZDqtJe_EDmz3oI0hpYijWUc3QVxMzcwuGXOfjNmN3Whl7pMxovjODg02_YTD0XWIoujPDzokC36MMJcwjhjnQnHRFezdHsMyjK3DaJJ1OFscXESbzRDcfz5yBxRUr68</recordid><startdate>19980301</startdate><enddate>19980301</enddate><creator>Guanti, Giuseppe</creator><creator>Riva, Renata</creator><creator>Cascio, Giuseppe</creator><creator>Manghisi, Elso</creator><creator>Morandotti, Grazia</creator><creator>Satta, Giuseppe</creator><creator>Sperning, Roberta</creator><general>Elsevier SAS</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980301</creationdate><title>A new class of cis-monobactam derivatives bearing a sulfamoyloxymethyl or an N-alkylsulfamoyloxymethyl group at position 4: Synthesis and antibacterial activity</title><author>Guanti, Giuseppe ; Riva, Renata ; Cascio, Giuseppe ; Manghisi, Elso ; Morandotti, Grazia ; Satta, Giuseppe ; Sperning, Roberta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-26c432ebac5b55fbbcf81ce6299148af9f460a358bc2006286dda79b5c1ee2503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Antibacterial activity</topic><topic>Antibacterial agents</topic><topic>Antibiotics. 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| fulltext | fulltext |
| identifier | ISSN: 0014-827X |
| ispartof | Farmaco (Società chimica italiana : 1989), 1998-03, Vol.53 (3), p.173-180 |
| issn | 0014-827X 1879-0569 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79962740 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Antibacterial activity Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Carumonam Escherichia coli - drug effects Medical sciences Molecular Structure Monobactams Monobactams - chemical synthesis Monobactams - pharmacology Pharmacology. Drug treatments Pseudomonas aeruginosa - drug effects Staphylococcus aureus - drug effects Sulfur Compounds - chemical synthesis Sulfur Compounds - pharmacology β-Lactams |
| title | A new class of cis-monobactam derivatives bearing a sulfamoyloxymethyl or an N-alkylsulfamoyloxymethyl group at position 4: Synthesis and antibacterial activity |
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