A new class of cis-monobactam derivatives bearing a sulfamoyloxymethyl or an N-alkylsulfamoyloxymethyl group at position 4: Synthesis and antibacterial activity

A new class of cis-monobactam derivatives bearing a sulfamoyloxymethyl or an N-alkylsulfamoyloxymethyl group at position 4: Synthesis and antibacterial activity

A new series of monobactam derivatives, bearing unsubstituted or N-monosubstituted sulfamoyloxymethyl groups in position 4 was synthesized either in racemic or in optically active form. Their in vitro antibacterial activity was tested in comparison with carumonam 1a and its methoxyimino derivative 1...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Farmaco (Società chimica italiana : 1989) 1998-03, Vol.53 (3), p.173-180
Hauptverfasser: Guanti, Giuseppe, Riva, Renata, Cascio, Giuseppe, Manghisi, Elso, Morandotti, Grazia, Satta, Giuseppe, Sperning, Roberta
Format: Artikel
Sprache:eng
Schlagworte:
Antibacterial activity
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Carumonam
Escherichia coli - drug effects
Medical sciences
Molecular Structure
Monobactams
Monobactams - chemical synthesis
Monobactams - pharmacology
Pharmacology. Drug treatments
Pseudomonas aeruginosa - drug effects
Staphylococcus aureus - drug effects
Sulfur Compounds - chemical synthesis
Sulfur Compounds - pharmacology
β-Lactams
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A new series of monobactam derivatives, bearing unsubstituted or N-monosubstituted sulfamoyloxymethyl groups in position 4 was synthesized either in racemic or in optically active form. Their in vitro antibacterial activity was tested in comparison with carumonam 1a and its methoxyimino derivative 1b.
ISSN:0014-827X
1879-0569
DOI:10.1016/S0014-827X(98)00004-4