Stimulation of p21ras upon T-cell activation
External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21 ras . The mechanism seems to involve a decrease in the activity...
Gespeichert in:
| Veröffentlicht in: | Nature (London) 1990-08, Vol.346 (6286), p.719-723 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 723 |
|---|---|
| container_issue | 6286 |
| container_start_page | 719 |
| container_title | Nature (London) |
| container_volume | 346 |
| creator | Downward, Julian Graves, Jonathan D. Warne, Patricia H. Rayter, Sydonia Cantrell, Doreen A. |
| description | External signals that control the activity of proteins encoded by the
ras
proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21
ras
. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21
ras
may therefore be an important mediator of the action of protein kinase C. |
| doi_str_mv | 10.1038/346719a0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79955527</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2232685256</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-141fc1e328f71c07cc887d67eda790f1bd36bd5464f565c156dab9c4a40ab4e73</originalsourceid><addsrcrecordid>eNplkFtLxDAUhIMo67oK_gGhIIiC1Zzc-yiLN1jwwfU5pGkiXXozaQX_vV13VdCnwzAfc4ZB6BjwFWCqrikTEjKDd9AUmBQpE0ruoinGRKVYUbGPDmJcYYw5SDZBE0IwZASm6PK5L-uhMn3ZNknrk45AMDEZulEuU-uqKjG2L9-_gEO0500V3dH2ztDL3e1y_pAunu4f5zeL1FKAPgUG3oKjRHkJFktrlZKFkK4wMsMe8oKKvOBMMM8Ft8BFYfLMMsOwyZmTdIbONrldaN8GF3tdl3HdxTSuHaKWWcY5J2vw9A-4aofQjN00IZQIxQkXI3W-oWxoYwzO6y6UtQkfGrBez6e_5xvRk23gkNeu-AG3e43-xcaPo9O8uvD78F_WJwvjdJ8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2232685256</pqid></control><display><type>article</type><title>Stimulation of p21ras upon T-cell activation</title><source>MEDLINE</source><source>Nature</source><source>Alma/SFX Local Collection</source><creator>Downward, Julian ; Graves, Jonathan D. ; Warne, Patricia H. ; Rayter, Sydonia ; Cantrell, Doreen A.</creator><creatorcontrib>Downward, Julian ; Graves, Jonathan D. ; Warne, Patricia H. ; Rayter, Sydonia ; Cantrell, Doreen A.</creatorcontrib><description>External signals that control the activity of proteins encoded by the
ras
proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21
ras
. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21
ras
may therefore be an important mediator of the action of protein kinase C.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/346719a0</identifier><identifier>PMID: 2201921</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Antigens ; Cell activation ; Coding ; Genes, ras ; GTP-binding protein ; GTPase-activating protein ; GTPase-Activating Proteins ; Guanosine triphosphatases ; Humanities and Social Sciences ; Humans ; In Vitro Techniques ; Influence ; Kinases ; Kinetics ; Lymphocyte Activation ; Lymphocytes ; Lymphocytes T ; multidisciplinary ; Oncogene Protein p21(ras) - genetics ; Oncogene Protein p21(ras) - metabolism ; Protein kinase C ; Protein Kinase C - metabolism ; Proteins ; Proteins - metabolism ; Proto-oncogenes ; ras GTPase-Activating Proteins ; Ras protein ; Receptors, Antigen, T-Cell - immunology ; Science ; Science (multidisciplinary) ; Signal Transduction ; Stimulation ; T-Lymphocytes - enzymology ; T-Lymphocytes - immunology</subject><ispartof>Nature (London), 1990-08, Vol.346 (6286), p.719-723</ispartof><rights>Springer Nature Limited 1990</rights><rights>Copyright Nature Publishing Group Aug 23, 1990</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-141fc1e328f71c07cc887d67eda790f1bd36bd5464f565c156dab9c4a40ab4e73</citedby><cites>FETCH-LOGICAL-c311t-141fc1e328f71c07cc887d67eda790f1bd36bd5464f565c156dab9c4a40ab4e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2201921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Downward, Julian</creatorcontrib><creatorcontrib>Graves, Jonathan D.</creatorcontrib><creatorcontrib>Warne, Patricia H.</creatorcontrib><creatorcontrib>Rayter, Sydonia</creatorcontrib><creatorcontrib>Cantrell, Doreen A.</creatorcontrib><title>Stimulation of p21ras upon T-cell activation</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>External signals that control the activity of proteins encoded by the
ras
proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21
ras
. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21
ras
may therefore be an important mediator of the action of protein kinase C.</description><subject>Antigens</subject><subject>Cell activation</subject><subject>Coding</subject><subject>Genes, ras</subject><subject>GTP-binding protein</subject><subject>GTPase-activating protein</subject><subject>GTPase-Activating Proteins</subject><subject>Guanosine triphosphatases</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Influence</subject><subject>Kinases</subject><subject>Kinetics</subject><subject>Lymphocyte Activation</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>multidisciplinary</subject><subject>Oncogene Protein p21(ras) - genetics</subject><subject>Oncogene Protein p21(ras) - metabolism</subject><subject>Protein kinase C</subject><subject>Protein Kinase C - metabolism</subject><subject>Proteins</subject><subject>Proteins - metabolism</subject><subject>Proto-oncogenes</subject><subject>ras GTPase-Activating Proteins</subject><subject>Ras protein</subject><subject>Receptors, Antigen, T-Cell - immunology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Signal Transduction</subject><subject>Stimulation</subject><subject>T-Lymphocytes - enzymology</subject><subject>T-Lymphocytes - immunology</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNplkFtLxDAUhIMo67oK_gGhIIiC1Zzc-yiLN1jwwfU5pGkiXXozaQX_vV13VdCnwzAfc4ZB6BjwFWCqrikTEjKDd9AUmBQpE0ruoinGRKVYUbGPDmJcYYw5SDZBE0IwZASm6PK5L-uhMn3ZNknrk45AMDEZulEuU-uqKjG2L9-_gEO0500V3dH2ztDL3e1y_pAunu4f5zeL1FKAPgUG3oKjRHkJFktrlZKFkK4wMsMe8oKKvOBMMM8Ft8BFYfLMMsOwyZmTdIbONrldaN8GF3tdl3HdxTSuHaKWWcY5J2vw9A-4aofQjN00IZQIxQkXI3W-oWxoYwzO6y6UtQkfGrBez6e_5xvRk23gkNeu-AG3e43-xcaPo9O8uvD78F_WJwvjdJ8</recordid><startdate>19900823</startdate><enddate>19900823</enddate><creator>Downward, Julian</creator><creator>Graves, Jonathan D.</creator><creator>Warne, Patricia H.</creator><creator>Rayter, Sydonia</creator><creator>Cantrell, Doreen A.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>19900823</creationdate><title>Stimulation of p21ras upon T-cell activation</title><author>Downward, Julian ; Graves, Jonathan D. ; Warne, Patricia H. ; Rayter, Sydonia ; Cantrell, Doreen A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-141fc1e328f71c07cc887d67eda790f1bd36bd5464f565c156dab9c4a40ab4e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Antigens</topic><topic>Cell activation</topic><topic>Coding</topic><topic>Genes, ras</topic><topic>GTP-binding protein</topic><topic>GTPase-activating protein</topic><topic>GTPase-Activating Proteins</topic><topic>Guanosine triphosphatases</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Influence</topic><topic>Kinases</topic><topic>Kinetics</topic><topic>Lymphocyte Activation</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>multidisciplinary</topic><topic>Oncogene Protein p21(ras) - genetics</topic><topic>Oncogene Protein p21(ras) - metabolism</topic><topic>Protein kinase C</topic><topic>Protein Kinase C - metabolism</topic><topic>Proteins</topic><topic>Proteins - metabolism</topic><topic>Proto-oncogenes</topic><topic>ras GTPase-Activating Proteins</topic><topic>Ras protein</topic><topic>Receptors, Antigen, T-Cell - immunology</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Signal Transduction</topic><topic>Stimulation</topic><topic>T-Lymphocytes - enzymology</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Downward, Julian</creatorcontrib><creatorcontrib>Graves, Jonathan D.</creatorcontrib><creatorcontrib>Warne, Patricia H.</creatorcontrib><creatorcontrib>Rayter, Sydonia</creatorcontrib><creatorcontrib>Cantrell, Doreen A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Downward, Julian</au><au>Graves, Jonathan D.</au><au>Warne, Patricia H.</au><au>Rayter, Sydonia</au><au>Cantrell, Doreen A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stimulation of p21ras upon T-cell activation</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1990-08-23</date><risdate>1990</risdate><volume>346</volume><issue>6286</issue><spage>719</spage><epage>723</epage><pages>719-723</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>External signals that control the activity of proteins encoded by the
ras
proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21
ras
. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21
ras
may therefore be an important mediator of the action of protein kinase C.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>2201921</pmid><doi>10.1038/346719a0</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1990-08, Vol.346 (6286), p.719-723 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79955527 |
| source | MEDLINE; Nature; Alma/SFX Local Collection |
| subjects | Antigens Cell activation Coding Genes, ras GTP-binding protein GTPase-activating protein GTPase-Activating Proteins Guanosine triphosphatases Humanities and Social Sciences Humans In Vitro Techniques Influence Kinases Kinetics Lymphocyte Activation Lymphocytes Lymphocytes T multidisciplinary Oncogene Protein p21(ras) - genetics Oncogene Protein p21(ras) - metabolism Protein kinase C Protein Kinase C - metabolism Proteins Proteins - metabolism Proto-oncogenes ras GTPase-Activating Proteins Ras protein Receptors, Antigen, T-Cell - immunology Science Science (multidisciplinary) Signal Transduction Stimulation T-Lymphocytes - enzymology T-Lymphocytes - immunology |
| title | Stimulation of p21ras upon T-cell activation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T21%3A44%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Stimulation%20of%20p21ras%20upon%20T-cell%20activation&rft.jtitle=Nature%20(London)&rft.au=Downward,%20Julian&rft.date=1990-08-23&rft.volume=346&rft.issue=6286&rft.spage=719&rft.epage=723&rft.pages=719-723&rft.issn=0028-0836&rft.eissn=1476-4687&rft_id=info:doi/10.1038/346719a0&rft_dat=%3Cproquest_cross%3E2232685256%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2232685256&rft_id=info:pmid/2201921&rfr_iscdi=true |