Stimulation of p21ras upon T-cell activation

External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21 ras . The mechanism seems to involve a decrease in the activity...

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Veröffentlicht in:	Nature (London) 1990-08, Vol.346 (6286), p.719-723
Hauptverfasser:	Downward, Julian, Graves, Jonathan D., Warne, Patricia H., Rayter, Sydonia, Cantrell, Doreen A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Cell activation Coding Genes, ras GTP-binding protein GTPase-activating protein GTPase-Activating Proteins Guanosine triphosphatases Humanities and Social Sciences Humans In Vitro Techniques Influence Kinases Kinetics Lymphocyte Activation Lymphocytes Lymphocytes T multidisciplinary Oncogene Protein p21(ras) - genetics Oncogene Protein p21(ras) - metabolism Protein kinase C Protein Kinase C - metabolism Proteins Proteins - metabolism Proto-oncogenes ras GTPase-Activating Proteins Ras protein Receptors, Antigen, T-Cell - immunology Science Science (multidisciplinary) Signal Transduction Stimulation T-Lymphocytes - enzymology T-Lymphocytes - immunology
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Beschreibung
Zusammenfassung:	External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21 ras . The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21 ras may therefore be an important mediator of the action of protein kinase C.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/346719a0