The sequence of the hemoregulatory peptide is present in Giα proteins
The hemoregulatory peptide PyroGlu‐Glu‐Asp‐Cys‐Lys (HP5b), which inhibits myelopoietic colony formation in vitro, is shown to be a sequence motif which is also part of the effector domain of Giα proteins. Out of 8 synthetic peptides with sequence variations of HP5b, those with the closest similarity...
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| Veröffentlicht in: | FEBS letters 1990-08, Vol.269 (1), p.11-14 |
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| container_title | FEBS letters |
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| creator | Laerum, Ole Didrik Frostad, Stein Tøn, Hege I. Kamp, Dietmar |
| description | The hemoregulatory peptide PyroGlu‐Glu‐Asp‐Cys‐Lys (HP5b), which inhibits myelopoietic colony formation in vitro, is shown to be a sequence motif which is also part of the effector domain of Giα proteins. Out of 8 synthetic peptides with sequence variations of HP5b, those with the closest similarity to the Giα sequence are biologically active. The inhibitory effect appears to be dependent on the blocked N‐tenninus. It is postulated that these peptides may interfere with signal transduction mediated by Gα proteins. |
| doi_str_mv | 10.1016/0014-5793(90)81106-X |
| format | Article |
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Out of 8 synthetic peptides with sequence variations of HP5b, those with the closest similarity to the Giα sequence are biologically active. The inhibitory effect appears to be dependent on the blocked N‐tenninus. It is postulated that these peptides may interfere with signal transduction mediated by Gα proteins.</description><subject>Amino Acid Sequence</subject><subject>Aminoacids, peptides. Hormones. Neuropeptides</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>G-protein</subject><subject>GTP-Binding Proteins - physiology</subject><subject>Hematopoiesis - drug effects</subject><subject>Hemopoiesis</subject><subject>Hemoregulatory peptide</subject><subject>In Vitro Techniques</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Oligopeptides - chemical synthesis</subject><subject>Oligopeptides - physiology</subject><subject>Proteins</subject><subject>Pyrrolidonecarboxylic Acid - analogs & derivatives</subject><subject>Structure-Activity Relationship</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1OwzAQhS0EKqVwA5CyAcEi4LHz5yVUTUGqxKZI2VlOOqFG-SNOhHosLsKZcEpUVtab92n8ZoaQS6D3QCF4oBQ81w8FvxX0LgKggZsckSlEIXe5F0THZHpATsmZMR_U6gjEhEwYQOj7dEri9RYdg589Vhk6de50Vm-xrFt87wvV1e3OabDp9AYdbZymRYNV5-jKWeqfb6vrDnVlzslJrgqDF-M7I2_xYj1_dlevy5f548ptGHiJywQNAXIepDYG5AgInhcEwueYpiyKUCjwKKQZijwHHiq2YTYygrITc0b5jNz89bUf28ymk6U2GRaFqrDujQyF8ETIfAtejWCflriRTatL1e7kOLj1r0dfmUwVeauqTJsDBoIJLnzPcvEf96UL3P37VA43kMOC5bBgKajc30AmMl48scEY6oLuqwn_BfmtesE</recordid><startdate>19900820</startdate><enddate>19900820</enddate><creator>Laerum, Ole Didrik</creator><creator>Frostad, Stein</creator><creator>Tøn, Hege I.</creator><creator>Kamp, Dietmar</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19900820</creationdate><title>The sequence of the hemoregulatory peptide is present in Giα proteins</title><author>Laerum, Ole Didrik ; Frostad, Stein ; Tøn, Hege I. ; Kamp, Dietmar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p214X-290711f36b8191fe1e14466953ebb288e9a1401bce9ff137a2d2018e1a1013203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Amino Acid Sequence</topic><topic>Aminoacids, peptides. Hormones. Neuropeptides</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>G-protein</topic><topic>GTP-Binding Proteins - physiology</topic><topic>Hematopoiesis - drug effects</topic><topic>Hemopoiesis</topic><topic>Hemoregulatory peptide</topic><topic>In Vitro Techniques</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>Oligopeptides - chemical synthesis</topic><topic>Oligopeptides - physiology</topic><topic>Proteins</topic><topic>Pyrrolidonecarboxylic Acid - analogs & derivatives</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laerum, Ole Didrik</creatorcontrib><creatorcontrib>Frostad, Stein</creatorcontrib><creatorcontrib>Tøn, Hege I.</creatorcontrib><creatorcontrib>Kamp, Dietmar</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laerum, Ole Didrik</au><au>Frostad, Stein</au><au>Tøn, Hege I.</au><au>Kamp, Dietmar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The sequence of the hemoregulatory peptide is present in Giα proteins</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1990-08-20</date><risdate>1990</risdate><volume>269</volume><issue>1</issue><spage>11</spage><epage>14</epage><pages>11-14</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>The hemoregulatory peptide PyroGlu‐Glu‐Asp‐Cys‐Lys (HP5b), which inhibits myelopoietic colony formation in vitro, is shown to be a sequence motif which is also part of the effector domain of Giα proteins. 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| ispartof | FEBS letters, 1990-08, Vol.269 (1), p.11-14 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology G-protein GTP-Binding Proteins - physiology Hematopoiesis - drug effects Hemopoiesis Hemoregulatory peptide In Vitro Techniques Mice Molecular Sequence Data Oligopeptides - chemical synthesis Oligopeptides - physiology Proteins Pyrrolidonecarboxylic Acid - analogs & derivatives Structure-Activity Relationship |
| title | The sequence of the hemoregulatory peptide is present in Giα proteins |
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