The sequence of the hemoregulatory peptide is present in Giα proteins

The hemoregulatory peptide PyroGlu‐Glu‐Asp‐Cys‐Lys (HP5b), which inhibits myelopoietic colony formation in vitro, is shown to be a sequence motif which is also part of the effector domain of Giα proteins. Out of 8 synthetic peptides with sequence variations of HP5b, those with the closest similarity...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	FEBS letters 1990-08, Vol.269 (1), p.11-14
Hauptverfasser:	Laerum, Ole Didrik, Frostad, Stein, Tøn, Hege I., Kamp, Dietmar
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology G-protein GTP-Binding Proteins - physiology Hematopoiesis - drug effects Hemopoiesis Hemoregulatory peptide In Vitro Techniques Mice Molecular Sequence Data Oligopeptides - chemical synthesis Oligopeptides - physiology Proteins Pyrrolidonecarboxylic Acid - analogs & derivatives Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The hemoregulatory peptide PyroGlu‐Glu‐Asp‐Cys‐Lys (HP5b), which inhibits myelopoietic colony formation in vitro, is shown to be a sequence motif which is also part of the effector domain of Giα proteins. Out of 8 synthetic peptides with sequence variations of HP5b, those with the closest similarity to the Giα sequence are biologically active. The inhibitory effect appears to be dependent on the blocked N‐tenninus. It is postulated that these peptides may interfere with signal transduction mediated by Gα proteins.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(90)81106-X