Porphyrin-linked oligonucleotides: Synthesis and sequence-specific modification of ssDNA

Oligonucleotide derivatives bearing hemin and deuterohemin groups were synthesized. The derivatives efficiently react with the complementary nucleotide sequence in ssDNA forming covalent adducts and piperidine-labile sites. In the case of the deuterohemin derivative, some direct cleavage of the targ...

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Veröffentlicht in:	FEBS letters 1990-08, Vol.269 (1), p.101-104
Hauptverfasser:	Frolova, E.I., Ivanova, E.M., Zarytova, V.F., Abramova, T.V., Vlassov, V.V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antisense oligonucleotide Base Sequence Biological and medical sciences Chemical Phenomena Chemistry Chromatography, High Pressure Liquid DNA affinity modification DNA Damage DNA, Single-Stranded Fundamental and applied biological sciences. Psychology Heme - analogs & derivatives Hemin Interactions. Associations Intermolecular phenomena Molecular biophysics Molecular Sequence Data Oligodeoxyribonucleotides Piperidines
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Beschreibung
Zusammenfassung:	Oligonucleotide derivatives bearing hemin and deuterohemin groups were synthesized. The derivatives efficiently react with the complementary nucleotide sequence in ssDNA forming covalent adducts and piperidine-labile sites. In the case of the deuterohemin derivative, some direct cleavage of the target DNA occurs.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(90)81129-C