Degree of Hypercoagulability and Hyperfibrinolysis is Related to Organ Failure and Prognosis after Burn Trauma

Severely burned patients often present a hypercoagulability situation. However, its magnitude, time course, and relationship with organ failure and outcome remains to be established. Forty-three patients were studied on the first and seventh day after burn for hypercoagulability and fibrinolysis par...

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Veröffentlicht in:	Thrombosis research 1998-01, Vol.89 (2), p.59-64
Hauptverfasser:	Garcı́a-Avello, A., Lorente, J.A., Cesar-Perez, J., Garcı́a-Frade, L.J., Alvarado, R., Arévalo, J.M., Navarro, J.L., Esteban, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens - metabolism Antithrombin III - metabolism Biological and medical sciences Biomarkers - blood Blood Coagulation Blood Coagulation Factors - metabolism Burns Burns - blood Burns - complications Disseminated Intravascular Coagulation - blood Disseminated Intravascular Coagulation - complications Factor VII - metabolism Factor VIIa - metabolism Female Fibrin Fibrinogen Degradation Products - metabolism Fibrinolysis Follow-Up Studies Humans Hypercoagulability Hyperfibrinolysis Hypofibrinolysis Male Medical sciences Middle Aged Multiorgan failure Multiple Organ Failure - blood Multiple Organ Failure - etiology Outcome Peptide Hydrolases - metabolism Protein C - metabolism Traumas. Diseases due to physical agents
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Zusammenfassung:	Severely burned patients often present a hypercoagulability situation. However, its magnitude, time course, and relationship with organ failure and outcome remains to be established. Forty-three patients were studied on the first and seventh day after burn for hypercoagulability and fibrinolysis parameters. A hypercoagulability and hyperfibrinolysis state was found the first day after burn demonstrated by high levels of activated factor VII (VIIa, p
ISSN:	0049-3848 1879-2472
DOI:	10.1016/S0049-3848(97)00291-0