CSF levels of carnitine in children with meningitis, neurologic disorders, acute gastroenteritis, and seizure

Carnitine concentrations in CSF, serum, and urine in normal febrile children and children with meningitis, neurologic disorders, and dehydration were studied. Carnitine levels in CSF were 1/10 compared with serum in normal febrile children. These levels increased two- to three-fold in the pathologic...

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Veröffentlicht in:	Neurology 1998-06, Vol.50 (6), p.1869-1871
Hauptverfasser:	SHINAWI, M, GRUENER, N, LERNER, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Biological and medical sciences Carnitine - blood Carnitine - cerebrospinal fluid Carnitine - urine Child Child, Preschool Female Fever - blood Fever - cerebrospinal fluid Fever - urine Gastroenteritis - blood Gastroenteritis - cerebrospinal fluid Gastroenteritis - urine Humans Infant Infant, Newborn Male Medical sciences Meningitis, Bacterial - blood Meningitis, Bacterial - cerebrospinal fluid Meningitis, Bacterial - urine Nervous system (semeiology, syndromes) Nervous system as a whole Nervous System Diseases - blood Nervous System Diseases - cerebrospinal fluid Nervous System Diseases - urine Neurology Osmolar Concentration Reference Values Seizures - blood Seizures - cerebrospinal fluid Seizures - urine Tropical medicine
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Zusammenfassung:	Carnitine concentrations in CSF, serum, and urine in normal febrile children and children with meningitis, neurologic disorders, and dehydration were studied. Carnitine levels in CSF were 1/10 compared with serum in normal febrile children. These levels increased two- to three-fold in the pathologic conditions studied. Since damage to the blood-brain barrier occurs in these conditions, higher blood-brain barrier permeability might explain CNS carnitine accumulation.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/WNL.50.6.1869