Short-term effect of glutamine on the incorporation of glucose-carbon into nucleic acids in Ehrlich ascites tumour cells

A slight but significant short-term incoporation (15 and 60 min) of glucose-carbon into DNA and RNA was detected in Ehrlich ascites tumour cells incubated in the presence of labelled glucose (5 mM). Glutamine (0.5 mM) increased the incorporation of glucose but did not modify the glycolytic flux.

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Bibliographische Detailangaben
Veröffentlicht in:	Biochimie 1990-04, Vol.72 (4), p.291-293
Hauptverfasser:	Medina, M.A., Carrascosa, J.M., Núñez de Castro, I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Carbohydrates Carbon - metabolism Carcinoma, Ehrlich Tumor - drug therapy Carcinoma, Ehrlich Tumor - metabolism DNA - metabolism Ehrlich tumour cells Fundamental and applied biological sciences. Psychology glucose Glucose - metabolism glutamine Glutamine - pharmacology nucleic acids Oses Other biological molecules RNA - metabolism
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Beschreibung
Zusammenfassung:	A slight but significant short-term incoporation (15 and 60 min) of glucose-carbon into DNA and RNA was detected in Ehrlich ascites tumour cells incubated in the presence of labelled glucose (5 mM). Glutamine (0.5 mM) increased the incorporation of glucose but did not modify the glycolytic flux.
ISSN:	0300-9084 1638-6183
DOI:	10.1016/0300-9084(90)90086-V