Treatment of hemoglobin Bart's hydrops with bone marrow transplantation

A 21-month-old girl with hemoglobin Bart's hydrops received bone marrow transplantation (BMT) from a matched sibling. No major BMT-related complications developed. Hemoglobin levels remained greater than 10 gm/dl for 20 months without blood transfusion support despite the presence of residual h...

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Veröffentlicht in:	The Journal of pediatrics 1998-06, Vol.132 (6), p.1039-1042
Hauptverfasser:	Chik, Ki-wai, Ming-kong Shing, Matthew, Li, Chi-kong, Leung, Ting-fan, Tsang, Kam-sze, Yuen, Hui-leung, Cheng, Shuk-han, Man-pan Yuen, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Thalassemia - blood alpha-Thalassemia - genetics alpha-Thalassemia - therapy Biological and medical sciences Bone Marrow Transplantation Female Globins - genetics Hemoglobins, Abnormal - genetics Humans Infant Medical sciences Miscellaneous Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Transplantation Conditioning
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Zusammenfassung:	A 21-month-old girl with hemoglobin Bart's hydrops received bone marrow transplantation (BMT) from a matched sibling. No major BMT-related complications developed. Hemoglobin levels remained greater than 10 gm/dl for 20 months without blood transfusion support despite the presence of residual host hemopoietic cells from 2 months after BMT. We suggest consideration of this therapeutic option for surviving patients. (J Pediatr 1998;132:1039-42.)
ISSN:	0022-3476 1097-6833
DOI:	10.1016/S0022-3476(98)70406-8