Sodium Homeostasis and Hormonal Responses During Dopaminergic Blockade in Normal Humans

Sodium Homeostasis and Hormonal Responses During Dopaminergic Blockade in Normal Humans

Six normal subjects were submitted to 2 h water immersion (WI) with and without pharmacological dopaminergic (DA) blockade with metoclopramide (MCP). Urinary sodium excretion showed a marked increase during WI alone while it was blunted during WI plus DA blockade. Plasma aldosterone was significantl...

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Veröffentlicht in:American journal of hypertension 1990-06, Vol.3 (6-Pt-2), p.87S-89S
Hauptverfasser: Coruzzi, Paolo, Musiari, Luisa, Biggi, Almerina, Carra, Nicoletta, Ravanetti, Carlo, Mxnuz, Pietro, Montanari, Alberto, Novarini, Almerico
Format: Artikel
Sprache:eng
Schlagworte:
Adult
aldosterone
Aldosterone - blood
atrial natriuretic factor
Atrial Natriuretic Factor - blood
Dopamine Antagonists
Homeostasis
Hormones - blood
Humans
Immersion
Male
Metoclopramide - pharmacology
Natriuresis
prostaglandins
Reference Values
Renin - blood
Sodium - metabolism
Water immersion
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Zusammenfassung:Six normal subjects were submitted to 2 h water immersion (WI) with and without pharmacological dopaminergic (DA) blockade with metoclopramide (MCP). Urinary sodium excretion showed a marked increase during WI alone while it was blunted during WI plus DA blockade. Plasma aldosterone was significantly suppressed by WI alone but remained unchanged during WI plus MCP. Plasma atrial natriuretic factor showed similar augmentation during WI alone and during WI plus MCP. The reduced sodium and 6-keto-PGFlα excretion, observed during WI plus MCP administration, suggests that dopamine might induce prostacyclin synthesis in the kidney during WI. Am J Hypertens 1990;3:87S-89S
ISSN:0895-7061
1941-7225
DOI:10.1093/ajh/3.6.87S