Detection of somatotropin receptors on human monocytes

The expression of somatotropin receptors on human peripheral blood monocytes was investigated. Binding of [ 125] somatotropin to human monocytes was found to be specific and saturable. The binding was rapid and time-dependent, and was abolished by pretreatment of monocytes with trypsin. Scatchard pl...

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Veröffentlicht in:	Immunology letters 1990-06, Vol.24 (3), p.199-202
Hauptverfasser:	Jafari, Parviz, Khansari, David N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology Growth hormone Growth Hormone - metabolism Humans Immunobiology Leukocytes, Mononuclear - analysis Monocyte monocytes Myeloid cells: ontogeny, maturation, markers, receptors Protein Binding Receptor Receptors, Somatotropin - analysis Receptors, Somatotropin - drug effects Receptors, Somatotropin - metabolism Somatotropin Trypsin - pharmacology
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Zusammenfassung:	The expression of somatotropin receptors on human peripheral blood monocytes was investigated. Binding of [ 125] somatotropin to human monocytes was found to be specific and saturable. The binding was rapid and time-dependent, and was abolished by pretreatment of monocytes with trypsin. Scatchard plot analysis revealed that each cell bore more than 8×10 3 binding sites with an affinity constant of 1×10 8 M −1.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/0165-2478(90)90048-U