Hyperthyroid Graves' Disease and Primary Hypothyroidism Caused by TSH Receptor Antibodies in Monozygotic Twins: Case Reports

A 33-year-old woman with signs and symptoms of hypothyroidism, including increased thyroid stimulating blocking antibody (TSBAb) activity, was referred for treatment by her local physician. Her monozygote twin was treated for hyperthyroid Graves' disease 10 years earlier. This case of hyperthyr...

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Veröffentlicht in:	Endocrine Journal 1998, Vol.45(1), pp.117-121
Hauptverfasser:	TANI, JUN-ICHI, YOSHIDA, KATSUMI, FUKAZAWA, HIROSHI, KISO, YOSHINORI, SAYAMA, NORIYO, MORI, KOUKI, AIZAWA, YOSHIHIKO, HORI, HIRUNOBU, NAKASATO, NAOKI, ABE, KEISHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Autoantibodies - blood Autoantibodies - immunology Diseases in Twins Female Graves Disease - immunology Graves' disease Human leukocyte antigen(HLA) Humans Hypothyroidism Hypothyroidism - immunology Immunoglobulins, Thyroid-Stimulating - blood Monozygote twins Receptors, Thyrotropin - blood Receptors, Thyrotropin - immunology Thyroid stimulating antibody (TSAb) Thyroid stimulating blocking antibody(TSBAb) TSH-receptor antibody (TRAb) Twins, Monozygotic
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Zusammenfassung:	A 33-year-old woman with signs and symptoms of hypothyroidism, including increased thyroid stimulating blocking antibody (TSBAb) activity, was referred for treatment by her local physician. Her monozygote twin was treated for hyperthyroid Graves' disease 10 years earlier. This case of hyperthyroidism and hypothyroidism in identical twins suggests the involvement of environmental factors in the pathogenesis of autoimmune thyroid diseases.
ISSN:	0918-8959 1348-4540
DOI:	10.1507/endocrj.45.117