BASIC AND CLINICAL STUDIES ON AZTREONAM IN OBSTETRIC AND GYNECOLOGIC INFECTIONS DURING THE PERINATAL PERIOD

BASIC AND CLINICAL STUDIES ON AZTREONAM IN OBSTETRIC AND GYNECOLOGIC INFECTIONS DURING THE PERINATAL PERIOD

The basic and clinical efficacies of aztreonam (AZT) were evaluated in obstetric and gynecologicinfections during the perinatal period. The results obtained are summarized below. 1. Concentrations of AZT in umbilical venous blood and amniotic fluid showed a good placental transfer of AZT. The rate o...

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Veröffentlicht in:Japanese journal of antibiotics 1990/04/25, Vol.43(4), pp.692-695
Hauptverfasser: MAKINODA, SATORU, NEGISHI, HIROAKI, OHKOHCHI, TOSHIHIRO, HANATANI, KAORU, SATOH, HIROSHI, TANAKA, TOSHINOBU, FUJIMOTO, SEIICHIRO
Format: Artikel
Sprache:jpn
Schlagworte:
Adult
Amniotic Fluid - metabolism
Aztreonam - pharmacokinetics
Aztreonam - therapeutic use
Bacterial Infections - drug therapy
Female
Fetal Blood - metabolism
Gram-Negative Bacteria
Humans
Maternal-Fetal Exchange
Pregnancy
Pregnancy Complications, Infectious - drug therapy
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Zusammenfassung:The basic and clinical efficacies of aztreonam (AZT) were evaluated in obstetric and gynecologicinfections during the perinatal period. The results obtained are summarized below. 1. Concentrations of AZT in umbilical venous blood and amniotic fluid showed a good placental transfer of AZT. The rate of placental transfer of AZT was very similar to rates for cephalosporins. 2. Since the clinical efficacy rate of AZT in the treatment of Gram-negative bacterial infections was 80.0%, AZT appears to be a useful drug against Gram-negative bacterial infections.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.43.692