In vivo hyperthermia induces expression of HSP70 mRNA in brain regions controlling the neuroendocrine response to stress

Regional localization of HSP70 expression in brain of rats exposed to increased ambient temperatures was examined using in situ hybridization. In addition to the cerebellar granule cell layer and choroid plexus, selective hybridization was observed in the hippocampal dentate gyrus, paraventricular a...

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Veröffentlicht in:	Brain research. Molecular brain research. 1990-06, Vol.8 (1), p.89-92
Hauptverfasser:	Blake, Michael J., Nowak, Thaddeus S., Holbrook, Nikki J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Brain - physiopathology Heat Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Hippocampus Hot Temperature HSP70 Hypothalamus In situ hybridization Male mRNA Neurosecretory Systems - physiopathology Nucleic Acid Hybridization Rats Rats, Inbred Strains RNA, Messenger - metabolism Stress Stress, Physiological - etiology Stress, Physiological - metabolism
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Zusammenfassung:	Regional localization of HSP70 expression in brain of rats exposed to increased ambient temperatures was examined using in situ hybridization. In addition to the cerebellar granule cell layer and choroid plexus, selective hybridization was observed in the hippocampal dentate gyrus, paraventricular and dorsomedial hypothalamic nuclei, median eminence, and medial habenula. Apparently, cells in brain regions coordinating the neuroendocrine response to stress show a preferential induction of cellular stress proteins in response to heat.
ISSN:	0169-328X 1872-6941
DOI:	10.1016/0169-328X(90)90014-5