Antineoplastic Agents, 178. Isolation and Structure of Lychnostatins 1 and 2 from the South American Lychnophora antillana

Bioassay-guided (P388 lymphocytic leukemia cell line) separation of a CH2Cl2/MeOH extract of Lychnophora antillana led to the isolation of two cytostatic (P-388, ED50 2.0 and 0.19 micrograms/ml, respectively) germacranolides designated lychnostatins 1 [1] and 2 [2]. Structural elucidation was based...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1990-03, Vol.53 (2), p.382-390
Hauptverfasser:	Pettit, George R, Herald, Delbert L, Cragg, Gordon M, Rideout, John A, Brown, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - isolation & purification Biological and medical sciences General pharmacology Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants - analysis Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology X-Ray Diffraction
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Zusammenfassung:	Bioassay-guided (P388 lymphocytic leukemia cell line) separation of a CH2Cl2/MeOH extract of Lychnophora antillana led to the isolation of two cytostatic (P-388, ED50 2.0 and 0.19 micrograms/ml, respectively) germacranolides designated lychnostatins 1 [1] and 2 [2]. Structural elucidation was based initially upon high field (400 MHz) nmr and electron impact mass spectral interpretations and unequivocally completed by X-ray crystal structure determinations.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np50068a017