Effects of M1 muscarinic receptor agonist on the central cholinergic system, evaluated by brain microdialysis

The effects of a novel M1-receptor agonist, AF102B (FKS-508; cis-2-methylspiro(1,3-oxathiolane-5,3')quinuclidine), on the central cholinergic system in vivo were evaluated by determination of acetylcholine (ACh) content in the rat brain after microwave irradiation and by measurement of ACh rele...

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Veröffentlicht in:	Neuroscience letters 1990-06, Vol.114 (1), p.95-100
Hauptverfasser:	OGANE, N, TAKADA, Y, IGA, Y, KAWANISHI, G, MIZOBE, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Animals Biological and medical sciences Brain - drug effects Brain - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebral Cortex - metabolism Corpus Striatum - metabolism Dialysis - methods Fundamental and applied biological sciences. Psychology Hippocampus - metabolism Kinetics Male Oxotremorine - pharmacology Parasympathomimetics - pharmacology Quinuclidines - pharmacology Rats Rats, Inbred Strains Scopolamine - pharmacology Thiophenes Time Factors Vertebrates: nervous system and sense organs
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