Effects of M1 muscarinic receptor agonist on the central cholinergic system, evaluated by brain microdialysis

Effects of M1 muscarinic receptor agonist on the central cholinergic system, evaluated by brain microdialysis

The effects of a novel M1-receptor agonist, AF102B (FKS-508; cis-2-methylspiro(1,3-oxathiolane-5,3')quinuclidine), on the central cholinergic system in vivo were evaluated by determination of acetylcholine (ACh) content in the rat brain after microwave irradiation and by measurement of ACh rele...

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Veröffentlicht in:Neuroscience letters 1990-06, Vol.114 (1), p.95-100
Hauptverfasser: OGANE, N, TAKADA, Y, IGA, Y, KAWANISHI, G, MIZOBE, F
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcholine - metabolism
Animals
Biological and medical sciences
Brain - drug effects
Brain - metabolism
Central nervous system
Central neurotransmission. Neuromudulation. Pathways and receptors
Cerebral Cortex - metabolism
Corpus Striatum - metabolism
Dialysis - methods
Fundamental and applied biological sciences. Psychology
Hippocampus - metabolism
Kinetics
Male
Oxotremorine - pharmacology
Parasympathomimetics - pharmacology
Quinuclidines - pharmacology
Rats
Rats, Inbred Strains
Scopolamine - pharmacology
Thiophenes
Time Factors
Vertebrates: nervous system and sense organs
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Zusammenfassung:The effects of a novel M1-receptor agonist, AF102B (FKS-508; cis-2-methylspiro(1,3-oxathiolane-5,3')quinuclidine), on the central cholinergic system in vivo were evaluated by determination of acetylcholine (ACh) content in the rat brain after microwave irradiation and by measurement of ACh release with microdialysis perfusion in freely moving rats. Intraperitoneal administration of AF102B resulted in a significant decrease of ACh content in the brain, while AF102B produced an increase of in vivo ACh release. The present results suggest that ACh content in the brain after treatment with muscarinic agents may be related to the changes of ACh release, in which both M1 and M2 muscarinic receptors may be involved.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(90)90434-b