Multiple agminate Spitz naevi
We report two patients with multiple agminate Spitz naevi (MASM), a rare disorder. In case 1, a 16-year-old girl, the results of chromosomal investigation of fibroblasts from the affected area (translocation 45, X, t(4; 7) (p14; p22) in a mosaic pattern) suggest that early during embryogenesis a de...
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| Veröffentlicht in: | Melanoma research 1998-04, Vol.8 (2), p.156-160 |
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| container_title | Melanoma research |
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| creator | Hulshof, M M van Haeringen, A Gruis, N A Snels, D C Bergman, W |
| description | We report two patients with multiple agminate Spitz naevi (MASM), a rare disorder. In case 1, a 16-year-old girl, the results of chromosomal investigation of fibroblasts from the affected area (translocation 45, X, t(4; 7) (p14; p22) in a mosaic pattern) suggest that early during embryogenesis a de novo reciprocal translocation has occurred between chromosomes 4 and 7. This resulted in the skin lesions as described on the right shoulder, arm and hand. The melanoma risk in MASM is also discussed. |
| doi_str_mv | 10.1097/00008390-199804000-00009 |
| format | Article |
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In case 1, a 16-year-old girl, the results of chromosomal investigation of fibroblasts from the affected area (translocation 45, X, t(4; 7) (p14; p22) in a mosaic pattern) suggest that early during embryogenesis a de novo reciprocal translocation has occurred between chromosomes 4 and 7. This resulted in the skin lesions as described on the right shoulder, arm and hand. 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In case 1, a 16-year-old girl, the results of chromosomal investigation of fibroblasts from the affected area (translocation 45, X, t(4; 7) (p14; p22) in a mosaic pattern) suggest that early during embryogenesis a de novo reciprocal translocation has occurred between chromosomes 4 and 7. This resulted in the skin lesions as described on the right shoulder, arm and hand. The melanoma risk in MASM is also discussed.</description><subject>Adolescent</subject><subject>Arm</subject><subject>Biopsy</subject><subject>Child, Preschool</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 4</subject><subject>Chromosomes, Human, Pair 7</subject><subject>Female</subject><subject>Hand</subject><subject>Humans</subject><subject>Male</subject><subject>Melanoma - epidemiology</subject><subject>Nevus, Epithelioid and Spindle Cell - genetics</subject><subject>Nevus, Epithelioid and Spindle Cell - pathology</subject><subject>Risk</subject><subject>Shoulder</subject><subject>Skin Neoplasms - genetics</subject><subject>Skin Neoplasms - pathology</subject><subject>Translocation, Genetic</subject><issn>0960-8931</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1OwzAQhH0AlVJ4hEo5cTOs49jxHlEFFKmIA3C2bMdBRvkjTpDg6Ulp6F5WO5rZkT5CEgbXDDC_gWkUR6AMUUE2XXQv4QlZAkqgCjk7I-cxfgCwnAu-IAuUDJTEJVk_jdUQuson5r0OjRl88tKF4SdpjP8KF-S0NFX0l_Nekbf7u9fNlu6eHx43tzvqOIOBSpOlIIwVyBxaZ7hBnikppZOmKIyyvsx8JqxIOTKb5YWwUkjnnGWFSJ3nK3J1-Nv17efo46DrEJ2vKtP4dow6RwTBkU9GdTC6vo2x96Xu-lCb_lsz0Hsa-p-GPtL4k3CKrueO0da-OAZnFPwXsbZbdw</recordid><startdate>19980401</startdate><enddate>19980401</enddate><creator>Hulshof, M M</creator><creator>van Haeringen, A</creator><creator>Gruis, N A</creator><creator>Snels, D C</creator><creator>Bergman, W</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980401</creationdate><title>Multiple agminate Spitz naevi</title><author>Hulshof, M M ; van Haeringen, A ; Gruis, N A ; Snels, D C ; Bergman, W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-6a4205ab591c9bca3a9348666c6adda8bef4e45b52391b47d5b656cccb1d52ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Arm</topic><topic>Biopsy</topic><topic>Child, Preschool</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 4</topic><topic>Chromosomes, Human, Pair 7</topic><topic>Female</topic><topic>Hand</topic><topic>Humans</topic><topic>Male</topic><topic>Melanoma - epidemiology</topic><topic>Nevus, Epithelioid and Spindle Cell - genetics</topic><topic>Nevus, Epithelioid and Spindle Cell - pathology</topic><topic>Risk</topic><topic>Shoulder</topic><topic>Skin Neoplasms - genetics</topic><topic>Skin Neoplasms - pathology</topic><topic>Translocation, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hulshof, M M</creatorcontrib><creatorcontrib>van Haeringen, A</creatorcontrib><creatorcontrib>Gruis, N A</creatorcontrib><creatorcontrib>Snels, D C</creatorcontrib><creatorcontrib>Bergman, W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Melanoma research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hulshof, M M</au><au>van Haeringen, A</au><au>Gruis, N A</au><au>Snels, D C</au><au>Bergman, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple agminate Spitz naevi</atitle><jtitle>Melanoma research</jtitle><addtitle>Melanoma Res</addtitle><date>1998-04-01</date><risdate>1998</risdate><volume>8</volume><issue>2</issue><spage>156</spage><epage>160</epage><pages>156-160</pages><issn>0960-8931</issn><abstract>We report two patients with multiple agminate Spitz naevi (MASM), a rare disorder. In case 1, a 16-year-old girl, the results of chromosomal investigation of fibroblasts from the affected area (translocation 45, X, t(4; 7) (p14; p22) in a mosaic pattern) suggest that early during embryogenesis a de novo reciprocal translocation has occurred between chromosomes 4 and 7. This resulted in the skin lesions as described on the right shoulder, arm and hand. The melanoma risk in MASM is also discussed.</abstract><cop>England</cop><pmid>9610869</pmid><doi>10.1097/00008390-199804000-00009</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Arm Biopsy Child, Preschool Chromosome Mapping Chromosomes, Human, Pair 4 Chromosomes, Human, Pair 7 Female Hand Humans Male Melanoma - epidemiology Nevus, Epithelioid and Spindle Cell - genetics Nevus, Epithelioid and Spindle Cell - pathology Risk Shoulder Skin Neoplasms - genetics Skin Neoplasms - pathology Translocation, Genetic |
| title | Multiple agminate Spitz naevi |
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