Multiple agminate Spitz naevi

We report two patients with multiple agminate Spitz naevi (MASM), a rare disorder. In case 1, a 16-year-old girl, the results of chromosomal investigation of fibroblasts from the affected area (translocation 45, X, t(4; 7) (p14; p22) in a mosaic pattern) suggest that early during embryogenesis a de...

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Veröffentlicht in:	Melanoma research 1998-04, Vol.8 (2), p.156-160
Hauptverfasser:	Hulshof, M M, van Haeringen, A, Gruis, N A, Snels, D C, Bergman, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Arm Biopsy Child, Preschool Chromosome Mapping Chromosomes, Human, Pair 4 Chromosomes, Human, Pair 7 Female Hand Humans Male Melanoma - epidemiology Nevus, Epithelioid and Spindle Cell - genetics Nevus, Epithelioid and Spindle Cell - pathology Risk Shoulder Skin Neoplasms - genetics Skin Neoplasms - pathology Translocation, Genetic
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Beschreibung
Zusammenfassung:	We report two patients with multiple agminate Spitz naevi (MASM), a rare disorder. In case 1, a 16-year-old girl, the results of chromosomal investigation of fibroblasts from the affected area (translocation 45, X, t(4; 7) (p14; p22) in a mosaic pattern) suggest that early during embryogenesis a de novo reciprocal translocation has occurred between chromosomes 4 and 7. This resulted in the skin lesions as described on the right shoulder, arm and hand. The melanoma risk in MASM is also discussed.
ISSN:	0960-8931
DOI:	10.1097/00008390-199804000-00009