Tm(DOTP)5−: A 23Na+ shift agent for perfused rat hearts

Tm(DOTP)5−, the thulium(III) complex of 1,4,7,10‐tetraazacyclododecane N,N′,N″,N‴tetra(methylenephosphonate), is introduced as a 23Na1 shift agent for use in discrimination of the NMR resonances of intra‐ and extracellular 23Na+ ions in perfused rat hearts. The novel shift agent is directly compared...

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Veröffentlicht in:	Magnetic resonance in medicine 1990-07, Vol.15 (1), p.25-32
Hauptverfasser:	Buster, Douglas C., Castro, M. Margarida C. A., Geraldes, Carlos F. G. C., Malloy, Craig R., Sherry, A. Dean, Siemers, Timothy C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiovascular system Heart Indicators and Reagents Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Spectroscopy Medical sciences Myocardium - analysis Oxazoles Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Perfusion Pyrimidinones Rats Sodium - analysis Thulium
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Zusammenfassung:	Tm(DOTP)5−, the thulium(III) complex of 1,4,7,10‐tetraazacyclododecane N,N′,N″,N‴tetra(methylenephosphonate), is introduced as a 23Na1 shift agent for use in discrimination of the NMR resonances of intra‐ and extracellular 23Na+ ions in perfused rat hearts. The novel shift agent is directly compared to the widely used Dy(TTHA)3‐ (dysprosium(III) triethylenetetraminehexaacetate). © 1990 Academic Press, Inc.
ISSN:	0740-3194 1522-2594
DOI:	10.1002/mrm.1910150104