Novel Cytotoxic Diterpenes, Excavatolides A−E, Isolated from the Formosan Gorgonian Briareum excavatum
The chemistry of Briareum excavatum, a Formosan gorgonian coral, was investigated. This study has led to the isolation of five novel marine natural products, excavatolides A−E (1−5), together with brianolide (6). The structures of the above compounds were established by spectral and chemical methods...
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Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 1998-05, Vol.61 (5), p.602-608 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The chemistry of Briareum excavatum, a Formosan gorgonian coral, was investigated. This study has led to the isolation of five novel marine natural products, excavatolides A−E (1−5), together with brianolide (6). The structures of the above compounds were established by spectral and chemical methods. The relative configuration of excavatolide B (2) was further confirmed by a single-crystal X-ray structure analysis. Cytotoxicity of these compounds toward various cancer cell lines also is described. |
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ISSN: | 0163-3864 1520-6025 |
DOI: | 10.1021/np970553w |