Diagnosis of Trisomy 18 Using Spontaneously Dividing Cells from Fetal Umbilical Cord Blood: A Novel Approach for Rapid Late Second and Third Trimester Prenatal Diagnosis

Diagnosis of Trisomy 18 Using Spontaneously Dividing Cells from Fetal Umbilical Cord Blood: A Novel Approach for Rapid Late Second and Third Trimester Prenatal Diagnosis

ABSTRACT Cytogenetic methodology recently developed by us allows spontaneously dividing cells in fetal cord blood to be used for rapid (24 hours) chromosome analysis. We utilized this methodology to diagnose trisomy 18 and facilitate clinical management in a 32-week pregnancy characterized by multip...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American journal of perinatology 1990-07, Vol.7 (3), p.211-213
Hauptverfasser: Tharapel, Avirachan T., Moretti, Michael L., Meyers, Carole M., Shulman, Lee P., Tipton, Robert E., Summitt, John B., Elias, Sherman, Wilroy, R. Sid, Epps, Michael, Simpson, Joe Leigh
Format: Artikel
Sprache:eng
Schlagworte:
Abnormalities, Multiple - diagnosis
Adult
Chromosomes, Human, Pair 18
Female
Fetal Blood - cytology
Fetal Growth Retardation - diagnosis
Humans
ORIGINAL ARTICLE
Pregnancy
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Prenatal Diagnosis - methods
Trisomy
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:ABSTRACT Cytogenetic methodology recently developed by us allows spontaneously dividing cells in fetal cord blood to be used for rapid (24 hours) chromosome analysis. We utilized this methodology to diagnose trisomy 18 and facilitate clinical management in a 32-week pregnancy characterized by multiple fetal anomalies and intrauterine growth retardation.
ISSN:0735-1631
1098-8785
DOI:10.1055/s-2007-999483