Isolation and Characterization of a New Pyrano[4′, 3′:6, 7]naphtho[1, 2-b]xanthene Antibiotic FD-594

During our screening of microbial metabolites for effective drugs against tumor cell lines, we discovered a new pyrano[4′, 3′:6, 7]naphtho[1, 2-b]xanthene derivative, FD-594 from the fermentation broth of Streptomyces sp. TA-0256. FD-594 shows moderate activity against tumor cell lines, comparative...

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Veröffentlicht in:	Journal of antibiotics 1998/03/25, Vol.51(3), pp.282-287
Hauptverfasser:	QIAO, YA-FANG, OKAZAKI, TADAYASU, ANDO, TSUTOMU, MIZOUE, KAZUTOSHI, KONDO, KATSUYA, EGUCHI, TADASHI, KAKINUMA, KATSUMI
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics (antibacterial agents, antifungal agents) Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - pharmacology Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Chemotherapic agents Fermentation Fundamental and applied biological sciences. Psychology HL-60 Cells Humans Mice Microbiology Pyrans - chemistry Pyrans - isolation & purification Pyrans - pharmacology Streptomyces Streptomyces - classification Streptomyces - metabolism Xanthenes - chemistry Xanthenes - isolation & purification Xanthenes - pharmacology
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Zusammenfassung:	During our screening of microbial metabolites for effective drugs against tumor cell lines, we discovered a new pyrano[4′, 3′:6, 7]naphtho[1, 2-b]xanthene derivative, FD-594 from the fermentation broth of Streptomyces sp. TA-0256. FD-594 shows moderate activity against tumor cell lines, comparative to that of adriamycin, as well as antibacterial activity against some Gram-positive bacteria.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.51.282