Epostatin, New Inhibitor of Dipeptidyl Peptidase II, Produced by Streptomyces sp. MJ995-OF5: II. Structure Elucidation

Epostatin, New Inhibitor of Dipeptidyl Peptidase II, Produced by Streptomyces sp. MJ995-OF5: II. Structure Elucidation

During the course of screening fermentation broths for new inhibitors of dipeptidyl peptidase II (EC 3.4.14.2), we discovered epostatin (C sub(23)H sub(33)N sub(3)O sub(5)) from Streptomyces sp. MJ995-OF5. The taxonomy of producing strain, fermentation, isolation, physico-chemical properties and bio...

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Veröffentlicht in:Journal of antibiotics 1998/03/25, Vol.51(3), pp.372-373
Hauptverfasser: AKIYAMA, TETSUO, SAWA, RYUICHI, NAGANAWA, HIROSHI, MURAOKA, YASUHIKO, AOYAGI, TAKAAKI, TAKEUCHI, TOMIO
Format: Artikel
Sprache:eng
Schlagworte:
Alanine - chemistry
Amides - chemistry
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - antagonists & inhibitors
Ethers, Cyclic - chemistry
Magnetic Resonance Spectroscopy
Serine Proteinase Inhibitors - chemistry
Streptomyces
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Zusammenfassung:During the course of screening fermentation broths for new inhibitors of dipeptidyl peptidase II (EC 3.4.14.2), we discovered epostatin (C sub(23)H sub(33)N sub(3)O sub(5)) from Streptomyces sp. MJ995-OF5. The taxonomy of producing strain, fermentation, isolation, physico-chemical properties and biological properties have been described in the preceding paper. Herein we report on the structure determination of epostatin on the basis of spectroscopic studies.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.51.372