Modelling cure rates using the Gompertz model with covariate information

We extend the modified Gompertz hazard function, first used by Cantor and Shuster for estimation of cure rates from pediatric clinical trials, by including covariate effects. The extended model provides a convenient method for estimation of the cure rate as a function of treatments and covariates. ©...

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Veröffentlicht in:	Statistics in medicine 1998-04, Vol.17 (8), p.831-839
Hauptverfasser:	Gieser, Peter W., Chang, Myron N., Rao, P. V., Shuster, Jonathan J., Pullen, Jeanette
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Child Computerized, statistical medical data processing and models in biomedicine Humans Likelihood Functions Linear Models Mathematical Computing Medical sciences Medical statistics Models, Statistical Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Prognosis Randomized Controlled Trials as Topic Regression Analysis Statistics, Nonparametric Survival Rate Treatment Outcome
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Zusammenfassung:	We extend the modified Gompertz hazard function, first used by Cantor and Shuster for estimation of cure rates from pediatric clinical trials, by including covariate effects. The extended model provides a convenient method for estimation of the cure rate as a function of treatments and covariates. © 1998 John Wiley & Sons, Ltd.
ISSN:	0277-6715 1097-0258
DOI:	10.1002/(SICI)1097-0258(19980430)17:8<831::AID-SIM790>3.0.CO;2-G