The impact of L1 retrotransposons on the human genome

The ‘master’ human mobile element, the L1 retrotransposon, has come of age as a biological entity. Knowledge of how it retrotransposes in vivo , how its proteins act to retrotranspose other poly A elements and the extent of its role in shaping the human genome should emerge rapidly over the next few...

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Veröffentlicht in:	Nature genetics 1998-05, Vol.19 (1), p.19-24
Hauptverfasser:	Kazazian, Haig H, Moran, John V
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Classical genetics, quantitative genetics, hybrids Fundamental and applied biological sciences. Psychology Gene Function Genetics of eukaryotes. Biological and molecular evolution Genome, Human Human Human Genetics Humans progress Retroelements
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Beschreibung
Zusammenfassung:	The ‘master’ human mobile element, the L1 retrotransposon, has come of age as a biological entity. Knowledge of how it retrotransposes in vivo , how its proteins act to retrotranspose other poly A elements and the extent of its role in shaping the human genome should emerge rapidly over the next few years. We review the impact of retrotransposons and how new insight is likely to lead to important practical applications for these intriguing mobile elements.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/ng0598-19