More support for the use of HIV combination assays

We have recently reported in the Journal a case of an HIV-2 infected person who was not detected using routine HIV-1 screening or confirmatory assays. This prompted us to determine if other HIV-2 infected persons may have been similarly mis-diagnosed. Since the initial report, we retested 600 indivi...

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Veröffentlicht in:	Journal of virological methods 1990-05, Vol.28 (2), p.217-218
Hauptverfasser:	Callahan, Johnny D., Constantine, Niel T., Watts, Douglas M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - diagnosis Acquired Immunodeficiency Syndrome - epidemiology Africa - epidemiology AIDS/HIV Biological and medical sciences Blotting, Western Enzyme-Linked Immunosorbent Assay Epidemiology Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology HIV-1 HIV-2 human immunodeficiency virus 1 Humans Microbiology Population Prevalence Virology
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Beschreibung
Zusammenfassung:	We have recently reported in the Journal a case of an HIV-2 infected person who was not detected using routine HIV-1 screening or confirmatory assays. This prompted us to determine if other HIV-2 infected persons may have been similarly mis-diagnosed. Since the initial report, we retested 600 individuals from 32 African countries or the Gulf Region, using the HIV-1/2 combination assay. Sera from these 600 individuals were originally tested by the Abbott HIV-1 recombinant ELISA and were negative. Upon retesting with the combination assay, one serum was found to be repeatedly reactive. The patient was from Ivory Coast in West Africa, making the diagnosis credible.
ISSN:	0166-0934 1879-0984
DOI:	10.1016/0166-0934(90)90037-G