Choriocapillaris Degeneration and Related Pathologic Changes in Human Diabetic Eyes

OBJECTIVES To measure the extent of choriocapillaris degeneration (CCD) in diabetic choroids and to study the association of CCD with choroidal neovascularization and pathologic changes in Bruch's membrane–like basal laminar deposits. MATERIALS AND METHODS Human choroids from 10 postmortem subj...

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Veröffentlicht in:Archives of ophthalmology (1960) 1998-05, Vol.116 (5), p.589-597
Hauptverfasser: Cao, Jingtai, McLeod, D. Scott, Merges, Carol A, Lutty, Gerard A
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Sprache:eng
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Zusammenfassung:OBJECTIVES To measure the extent of choriocapillaris degeneration (CCD) in diabetic choroids and to study the association of CCD with choroidal neovascularization and pathologic changes in Bruch's membrane–like basal laminar deposits. MATERIALS AND METHODS Human choroids from 10 postmortem subjects (diabetic, 5 [group 1]; nondiabetic, 5 [group 2]) were incubated for the histochemical demonstration of alkaline phosphatase and nonspecific esterase activities, permitting analysis of the choroidal vasculature and polymorphonuclear leukocytes, respectively. The tissue was then flat embedded and sectioned for structural analysis. Areas of CCD were measured in the flat perspective by computer-assisted image analysis and verified in cross-sections of flat-embedded tissue. RESULTS The CCD in choroids from subjects with diabetes (group 1) appeared in 2 patterns: diffuse (partial loss of alkaline phosphatase activity in a poorly defined area, ie, degeneration of some capillary segments) and focal (complete degeneration of choriocapillaris or loss of alkaline phosphatase activity in a relatively well-defined area). The mean±SD percentage of the choroid with focal CCD in group 1 was 5.08±1.13% of the total choroidal area vs 1.16±0.35% in group 2 (P
ISSN:0003-9950
2168-6165
1538-3601
2168-6173
DOI:10.1001/archopht.116.5.589