Transient Angiolymphoid Hyperplasia and Kaposi's Sarcoma after Primary Infection with Human Herpesvirus 8 in a Patient with Human Immunodeficiency Virus Infection

DNA sequences of human herpesvirus 8 (HHV-8) have been detected in all forms of Kaposi's sarcoma. 1 – 3 HHV-8 has also been detected in primary effusion lymphomas, 4 Castleman's disease, 5 and multiple myeloma 6 and reported anecdotally in cases of angioimmunoblastic lymphadenopathy and germinal-center hyperplasia. 7 Indirect immunofluorescence and immunoblot assays, based on antigens from a latently infected lymphoma cell line, have shown that HHV-8 is not a ubiquitous viral infection in humans. The overall seroprevalence of HHV-8 is less than 5 percent in the United States and United Kingdom, up to 35 percent in southern Italy, and over 50 percent in East Africa. . . .