Advances in periodontal diagnosis. 6. Proteolytic and hydrolytic enzymes of inflammatory cell origin

Potential proteolytic and hydrolytic enzymes of inflammatory cell origin might serve as biomarkers of periodontal disease activity. The role of these enzymes in periodontal pathology, particularly in respect of collagen and proteoglycan degradation, is discussed. The cellular location of these enzym...

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Veröffentlicht in:	British dental journal 1998-03, Vol.184 (6), p.268-271
Hauptverfasser:	Eley, B M, Cox, S W
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers - analysis Collagen - metabolism Collagenases - analysis Connective Tissue - metabolism Dentistry Enzyme Inhibitors - pharmacology Glycosaminoglycans - metabolism Humans Hydrolases - analysis Hydrolases - antagonists & inhibitors Inflammation Macrophages - enzymology Mast Cells - enzymology Neutrophils - enzymology Peptide Hydrolases - analysis Periodontal Diseases - diagnosis Periodontal Diseases - enzymology Periodontal Diseases - pathology Periodontium - metabolism Protease Inhibitors - pharmacology Proteoglycans - metabolism
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Zusammenfassung:	Potential proteolytic and hydrolytic enzymes of inflammatory cell origin might serve as biomarkers of periodontal disease activity. The role of these enzymes in periodontal pathology, particularly in respect of collagen and proteoglycan degradation, is discussed. The cellular location of these enzymes and their normal control mechanisms by endogenous inhibitors is described
ISSN:	0007-0610 1476-5373
DOI:	10.1038/sj.bdj.4809599