Does reversed-type anaphylaxis in healthy subjects mimic a real allergic reaction?
Summary Immediate and late cutaneous reactions were induced in healthy and atopic subjects by anti‐IgE challenge and a skin‐window technique was used in order to verify if the pattern of cells observed at 24 hr was similar in both groups. The study was first performed under basal conditions, and in...
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| Veröffentlicht in: | Clinical and experimental allergy 1990-05, Vol.20 (3), p.269-272 |
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| container_title | Clinical and experimental allergy |
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| creator | HENOCQ, E. RIHOUX, J.-P. |
| description | Summary
Immediate and late cutaneous reactions were induced in healthy and atopic subjects by anti‐IgE challenge and a skin‐window technique was used in order to verify if the pattern of cells observed at 24 hr was similar in both groups. The study was first performed under basal conditions, and in a second double‐blind cross‐over step, it was performed again during treatment with cetirizine 10 mg b.i.d. and terfenadine 60 mg b.i.d. Anti‐IgE challenge was followed by a significant eosinophil accumulation in atopic subjects only. Cetirizine significantly inhibited this phenomenon while terfenadine showed a mild nonsignificant inhibitory effect. |
| doi_str_mv | 10.1111/j.1365-2222.1990.tb02682.x |
| format | Article |
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Immediate and late cutaneous reactions were induced in healthy and atopic subjects by anti‐IgE challenge and a skin‐window technique was used in order to verify if the pattern of cells observed at 24 hr was similar in both groups. The study was first performed under basal conditions, and in a second double‐blind cross‐over step, it was performed again during treatment with cetirizine 10 mg b.i.d. and terfenadine 60 mg b.i.d. Anti‐IgE challenge was followed by a significant eosinophil accumulation in atopic subjects only. Cetirizine significantly inhibited this phenomenon while terfenadine showed a mild nonsignificant inhibitory effect.</description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1111/j.1365-2222.1990.tb02682.x</identifier><identifier>PMID: 1973069</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Anaphylaxis - immunology ; Antigen-Antibody Reactions - drug effects ; Antigen-Antibody Reactions - immunology ; Cell Movement - drug effects ; Cetirizine ; Double-Blind Method ; Eosinophils - analysis ; Female ; Histamine H1 Antagonists - immunology ; Histamine H1 Antagonists - pharmacology ; Humans ; Hydroxyzine - analogs & derivatives ; Hydroxyzine - immunology ; Hydroxyzine - pharmacology ; Hypersensitivity, Delayed - immunology ; Hypersensitivity, Immediate - immunology ; Immunoglobulin E - immunology ; Male ; Random Allocation ; Skin - cytology ; Skin - immunology ; Skin Window Technique</subject><ispartof>Clinical and experimental allergy, 1990-05, Vol.20 (3), p.269-272</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4079-aa6046d211dde931290682e23fb334262ca9c2470073121d0f0948cff62284f33</citedby><cites>FETCH-LOGICAL-c4079-aa6046d211dde931290682e23fb334262ca9c2470073121d0f0948cff62284f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2222.1990.tb02682.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2222.1990.tb02682.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1973069$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HENOCQ, E.</creatorcontrib><creatorcontrib>RIHOUX, J.-P.</creatorcontrib><title>Does reversed-type anaphylaxis in healthy subjects mimic a real allergic reaction?</title><title>Clinical and experimental allergy</title><addtitle>Clin Exp Allergy</addtitle><description>Summary
Immediate and late cutaneous reactions were induced in healthy and atopic subjects by anti‐IgE challenge and a skin‐window technique was used in order to verify if the pattern of cells observed at 24 hr was similar in both groups. The study was first performed under basal conditions, and in a second double‐blind cross‐over step, it was performed again during treatment with cetirizine 10 mg b.i.d. and terfenadine 60 mg b.i.d. Anti‐IgE challenge was followed by a significant eosinophil accumulation in atopic subjects only. Cetirizine significantly inhibited this phenomenon while terfenadine showed a mild nonsignificant inhibitory effect.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anaphylaxis - immunology</subject><subject>Antigen-Antibody Reactions - drug effects</subject><subject>Antigen-Antibody Reactions - immunology</subject><subject>Cell Movement - drug effects</subject><subject>Cetirizine</subject><subject>Double-Blind Method</subject><subject>Eosinophils - analysis</subject><subject>Female</subject><subject>Histamine H1 Antagonists - immunology</subject><subject>Histamine H1 Antagonists - pharmacology</subject><subject>Humans</subject><subject>Hydroxyzine - analogs & derivatives</subject><subject>Hydroxyzine - immunology</subject><subject>Hydroxyzine - pharmacology</subject><subject>Hypersensitivity, Delayed - immunology</subject><subject>Hypersensitivity, Immediate - immunology</subject><subject>Immunoglobulin E - immunology</subject><subject>Male</subject><subject>Random Allocation</subject><subject>Skin - cytology</subject><subject>Skin - immunology</subject><subject>Skin Window Technique</subject><issn>0954-7894</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkElPwzAQhS0EgrL8BKSIA7cEb01iDiBUoCA2iUUcLdeZUBenKXYKzb_HJRWcmcto9Oa90XwIHRCckFBHk4SwtB_TUAkRAifNCNM0p8liDfV-pXXUw6LP4ywXfAttez_BGLO-yDfRJhEZw6noocfzGnzk4BOchyJu2hlEaqpm49aqhfGRmUZjULYZt5GfjyagGx9VpjI6UsGlbKSsBfcW5jDpxtTT0120USrrYW_Vd9DL5cXz4Cq-fRheD85uY81xJmKlUszTghJSFCAYoQKHF4CycsQYpynVSmjKM4yzIJICl1jwXJdlSmnOS8Z20GGXO3P1xxx8IyvjNVirplDPvcxEHi7kNCwed4va1d47KOXMmUq5VhIsl0DlRC6pySU1uQQqV0DlIpj3V1fmowqKP2tHMOgnnf5lLLT_SJaDizP6ExB3AcY3sPgNUO5dphnL-vL1fijvLgl_emZDecO-AZFfk-M</recordid><startdate>199005</startdate><enddate>199005</enddate><creator>HENOCQ, E.</creator><creator>RIHOUX, J.-P.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199005</creationdate><title>Does reversed-type anaphylaxis in healthy subjects mimic a real allergic reaction?</title><author>HENOCQ, E. ; RIHOUX, J.-P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4079-aa6046d211dde931290682e23fb334262ca9c2470073121d0f0948cff62284f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anaphylaxis - immunology</topic><topic>Antigen-Antibody Reactions - drug effects</topic><topic>Antigen-Antibody Reactions - immunology</topic><topic>Cell Movement - drug effects</topic><topic>Cetirizine</topic><topic>Double-Blind Method</topic><topic>Eosinophils - analysis</topic><topic>Female</topic><topic>Histamine H1 Antagonists - immunology</topic><topic>Histamine H1 Antagonists - pharmacology</topic><topic>Humans</topic><topic>Hydroxyzine - analogs & derivatives</topic><topic>Hydroxyzine - immunology</topic><topic>Hydroxyzine - pharmacology</topic><topic>Hypersensitivity, Delayed - immunology</topic><topic>Hypersensitivity, Immediate - immunology</topic><topic>Immunoglobulin E - immunology</topic><topic>Male</topic><topic>Random Allocation</topic><topic>Skin - cytology</topic><topic>Skin - immunology</topic><topic>Skin Window Technique</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HENOCQ, E.</creatorcontrib><creatorcontrib>RIHOUX, J.-P.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HENOCQ, E.</au><au>RIHOUX, J.-P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does reversed-type anaphylaxis in healthy subjects mimic a real allergic reaction?</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clin Exp Allergy</addtitle><date>1990-05</date><risdate>1990</risdate><volume>20</volume><issue>3</issue><spage>269</spage><epage>272</epage><pages>269-272</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract>Summary
Immediate and late cutaneous reactions were induced in healthy and atopic subjects by anti‐IgE challenge and a skin‐window technique was used in order to verify if the pattern of cells observed at 24 hr was similar in both groups. The study was first performed under basal conditions, and in a second double‐blind cross‐over step, it was performed again during treatment with cetirizine 10 mg b.i.d. and terfenadine 60 mg b.i.d. Anti‐IgE challenge was followed by a significant eosinophil accumulation in atopic subjects only. Cetirizine significantly inhibited this phenomenon while terfenadine showed a mild nonsignificant inhibitory effect.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>1973069</pmid><doi>10.1111/j.1365-2222.1990.tb02682.x</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-7894 |
| ispartof | Clinical and experimental allergy, 1990-05, Vol.20 (3), p.269-272 |
| issn | 0954-7894 1365-2222 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79860482 |
| source | MEDLINE; Wiley Journals |
| subjects | Adolescent Adult Anaphylaxis - immunology Antigen-Antibody Reactions - drug effects Antigen-Antibody Reactions - immunology Cell Movement - drug effects Cetirizine Double-Blind Method Eosinophils - analysis Female Histamine H1 Antagonists - immunology Histamine H1 Antagonists - pharmacology Humans Hydroxyzine - analogs & derivatives Hydroxyzine - immunology Hydroxyzine - pharmacology Hypersensitivity, Delayed - immunology Hypersensitivity, Immediate - immunology Immunoglobulin E - immunology Male Random Allocation Skin - cytology Skin - immunology Skin Window Technique |
| title | Does reversed-type anaphylaxis in healthy subjects mimic a real allergic reaction? |
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