Does reversed-type anaphylaxis in healthy subjects mimic a real allergic reaction?

Summary Immediate and late cutaneous reactions were induced in healthy and atopic subjects by anti‐IgE challenge and a skin‐window technique was used in order to verify if the pattern of cells observed at 24 hr was similar in both groups. The study was first performed under basal conditions, and in...

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Veröffentlicht in:Clinical and experimental allergy 1990-05, Vol.20 (3), p.269-272
Hauptverfasser: HENOCQ, E., RIHOUX, J.-P.
Format: Artikel
Sprache:eng
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Zusammenfassung:Summary Immediate and late cutaneous reactions were induced in healthy and atopic subjects by anti‐IgE challenge and a skin‐window technique was used in order to verify if the pattern of cells observed at 24 hr was similar in both groups. The study was first performed under basal conditions, and in a second double‐blind cross‐over step, it was performed again during treatment with cetirizine 10 mg b.i.d. and terfenadine 60 mg b.i.d. Anti‐IgE challenge was followed by a significant eosinophil accumulation in atopic subjects only. Cetirizine significantly inhibited this phenomenon while terfenadine showed a mild nonsignificant inhibitory effect.
ISSN:0954-7894
1365-2222
DOI:10.1111/j.1365-2222.1990.tb02682.x