The relative proportion of H1° and A24 is reversed in oligodendrocytes during rat brain development

1. The histone complement of oligodendrocyte chromatin at different stages of brain development was studied after acid extraction of nuclei. 2. HCl-soluble proteins were analyzed by different electrophoretic techniques. 3. Our results show an increase in the concentration of histone H1(0) with diffe...

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Veröffentlicht in:	Cellular and molecular neurobiology 1990-06, Vol.10 (2), p.267-274
Hauptverfasser:	DI LIEGRO, I, CESTELLI, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Animals Biochemistry and metabolism Biological and medical sciences Brain - growth & development Brain - metabolism Central nervous system Fundamental and applied biological sciences. Psychology Histones - metabolism Histones - physiology Oligodendroglia - metabolism Oligodendroglia - physiology Rats Ubiquitins Vertebrates: nervous system and sense organs
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Zusammenfassung:	1. The histone complement of oligodendrocyte chromatin at different stages of brain development was studied after acid extraction of nuclei. 2. HCl-soluble proteins were analyzed by different electrophoretic techniques. 3. Our results show an increase in the concentration of histone H1(0) with differentiation. 4. The increase in H1(0) is accompanied by a concomitant decrease in the total amount of the ubiquitinated form of histone H2A (A24).
ISSN:	0272-4340 1573-6830
DOI:	10.1007/BF00734579