Comparison of gene expression of the dopamine D-2 receptor and DARPP-32 in rat brain, pituitary and adrenal gland

In situ hybridization histochemistry was used to compare the distribution of dopamine D-2 receptor mRNA and DARPP-32 mRNA in rat brain, pituitary and adrenal gland. In many regions such as the caudate nucleus, nucleus accumbens and olfactory tubercle, there was an excellent correlation with dopamine...

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Veröffentlicht in:	European journal of pharmacology 1990-04, Vol.188 (4), p.277-281
Hauptverfasser:	Schalling, Martin, Dagerlind, Åke, Goldstein, Menek, Ehrlich, Michelle, Greengard, Paul, Hökfelt, Tomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Adrenal Glands - anatomy & histology Adrenal Glands - drug effects Adrenal Glands - metabolism Animals Autoradiography Biological and medical sciences Brain - anatomy & histology Brain Chemistry - drug effects Caudate nucleus Cell receptors Cell structures and functions Dopamine and cAMP-Regulated Phosphoprotein 32 Dopamine D-1 receptors Fundamental and applied biological sciences. Psychology Gene Expression Histocytochemistry Hybridization (in situ) Mesencephalon - drug effects Mesencephalon - enzymology Mesencephalon - metabolism Molecular and cellular biology Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) Nerve Tissue Proteins - pharmacology Nucleic Acid Hybridization Nucleus accumbens Phosphoproteins Pituitary Gland - anatomy & histology Pituitary Gland - drug effects Pituitary Gland - metabolism Rats Receptors, Dopamine - drug effects Receptors, Dopamine - genetics Receptors, Dopamine - metabolism RNA, Messenger - metabolism Substantia nigra Tyrosine 3-Monooxygenase - biosynthesis Tyrosine 3-Monooxygenase - genetics Tyrosine hydroxylase
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Zusammenfassung:	In situ hybridization histochemistry was used to compare the distribution of dopamine D-2 receptor mRNA and DARPP-32 mRNA in rat brain, pituitary and adrenal gland. In many regions such as the caudate nucleus, nucleus accumbens and olfactory tubercle, there was an excellent correlation with dopamine receptor binding studies, whereas in some discrete brain regions mismatches were observed.
ISSN:	0922-4106 0014-2999 1879-0712
DOI:	10.1016/0922-4106(90)90012-M