Norepinephrine and serotonin increase the vasoconstrictor response of the perfused rat tail artery to changes in cytosolic Ca2

Norepinephrine and serotonin increase the vasoconstrictor response of the perfused rat tail artery to changes in cytosolic Ca2

Vasoconstriction and changes in cytosolic free Ca2+ concentrations (fura 2 with dual wavelength excitation) were measured simultaneously in the perfused tail artery of the rat. Vasoconstrictors (norepinephrine and 5-HT) appear to modulate contraction not only by changing the cytosolic free Ca2+ conc...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European journal of pharmacology 1990-04, Vol.179 (3), p.469-471
Hauptverfasser: THORIN-TRESCASES, N, OSTER, L, ATKINSON, J, CAPDEVILLE, C
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Arteries - drug effects
Benzofurans
Biological and medical sciences
Calcium - metabolism
Cardiovascular system
Cytosol - metabolism
Fura-2
In Vitro Techniques
Male
Medical sciences
Miscellaneous
Muscle, Smooth, Vascular - drug effects
Norepinephrine - pharmacology
Pharmacology. Drug treatments
Rats
Rats, Inbred Strains
Regional Blood Flow - drug effects
Serotonin - pharmacology
Tail - blood supply
Vasoconstriction - drug effects
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Vasoconstriction and changes in cytosolic free Ca2+ concentrations (fura 2 with dual wavelength excitation) were measured simultaneously in the perfused tail artery of the rat. Vasoconstrictors (norepinephrine and 5-HT) appear to modulate contraction not only by changing the cytosolic free Ca2+ concentration but also by modifying the sensitivity of the contractile proteins to Ca2+.
ISSN:0014-2999
1879-0712
DOI:10.1016/0014-2999(90)90191-8