Ubiquitin-conjugating enzymes: novel regulators of eukaryotic cells

Covalent attachment of ubiquitin to cellular proteins is essential for cell viability and is catalysed by a set of distinct ubiquitin-conjugating enzymes. Individual members of this novel enzyme family mediate strikingly diverse functions, including DNA repair, cell cycle control, selective protein...

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Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 1990-05, Vol.15 (5), p.195-198
Hauptverfasser:	Jentsch, Stefan, Seufert, Wolfgang, Sommer, Thomas, Reins, Hans-Albert
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells - enzymology Eukaryotic Cells - enzymology Ligases - physiology Ubiquitin-Protein Ligases
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Covalent attachment of ubiquitin to cellular proteins is essential for cell viability and is catalysed by a set of distinct ubiquitin-conjugating enzymes. Individual members of this novel enzyme family mediate strikingly diverse functions, including DNA repair, cell cycle control, selective protein degradation and essential functions of the stress response.
ISSN:	0968-0004 1362-4326
DOI:	10.1016/0968-0004(90)90161-4