Production of arachidonic acid metabolites by caprine alveolar macrophages

The in vitro release of arachidonic acid (AA) metabolites from caprine alveolar macrophages (CAM) stimulated with the calcium ionophore A23187 or opsonized zymosan was examined. Leukotriene B4 [5(S),12(R)-6,14-cis-8,10-trans-dihydroxyeicosatetraenoic acid] was the major AA metabolite elicited with e...

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Veröffentlicht in:	Inflammation 1990-06, Vol.14 (3), p.239-245
Hauptverfasser:	ENGLEN, M. D, TAYLOR, S. M, LAEGREID, W, SILFLOW, R. M, BANKS, K. L, LEID, R. W
Format:	Artikel
Sprache:	eng
Schlagworte:	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid Animals Arachidonic Acid Arachidonic Acids - metabolism Biological and medical sciences Bronchoalveolar Lavage Fluid - cytology Calcimycin - pharmacology Cell metabolism, cell oxidation Cell physiology Fatty Acids, Unsaturated - biosynthesis Fundamental and applied biological sciences. Psychology Goats - metabolism Hydroxyeicosatetraenoic Acids - biosynthesis Leukotriene B4 - biosynthesis Lipid Metabolism Macrophages - drug effects Macrophages - metabolism Molecular and cellular biology Zymosan - pharmacology
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Zusammenfassung:	The in vitro release of arachidonic acid (AA) metabolites from caprine alveolar macrophages (CAM) stimulated with the calcium ionophore A23187 or opsonized zymosan was examined. Leukotriene B4 [5(S),12(R)-6,14-cis-8,10-trans-dihydroxyeicosatetraenoic acid] was the major AA metabolite elicited with either agonist; smaller amounts of 12- and 5-mono-hydroxyeicosatetraenoic acid (HETE), and 12-hydroxyheptadecatrienoic acid (HHT) were also detected. Zymosan stimulation also caused the release of very small quantities of prostaglandins E2 and F2 alpha, and thromboxane B2. Our report is the first to describe arachidonic acid metabolism in CAM.
ISSN:	0360-3997 1573-2576
DOI:	10.1007/BF00915808