Pharmacokinetics in sheep and cattle of albendazole administered by an intraruminal slow release capsule

Forty sheep and 40 heifers were dosed with an intraruminal slow release capsule (irsrc) constructed to deliver albendazole (abz) at a low daily dosage for three months. Blood samples were collected at standardised intervals for 110 days and analysed by high performance liquid chromatography for the...

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Veröffentlicht in:Research in veterinary science 1990-05, Vol.48 (3), p.271-275
Hauptverfasser: DELATOUR, P., BENOIT, E., LECHENET, J., BESSE, S.
Format: Artikel
Sprache:eng
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Zusammenfassung:Forty sheep and 40 heifers were dosed with an intraruminal slow release capsule (irsrc) constructed to deliver albendazole (abz) at a low daily dosage for three months. Blood samples were collected at standardised intervals for 110 days and analysed by high performance liquid chromatography for the quantification of the two main metabolites sulphoxide (so.abz) and sulphone (so2abz). The plasma profiles show sustained concentrations of the active metabolite so.abz for 105 days in sheep (m = 0·06 ± 0·032 μg ml−1) and 85 days in cattle (m = 0·10 ± 0·019 μg ml−1). In both species, the proportions of the metabolites were inverted compared to that observed after a single dosage. The bioavailability of abz after the administration of the irsrc compared with a drench was reduced in sheep but increased in cattle. The irsrc exhibited a preventive and therapeutic effect for at least three months.
ISSN:0034-5288
1532-2661
DOI:10.1016/S0034-5288(18)31012-9