Mucosal transmission of virulent and avirulent lentiviruses in macaques

Sexual transmission of human immunodeficiency virus provides an efficient mode for virus spread and poses unique challenges to vaccine developers. Host and viral factors that affect transmission have been studied by epidemiological approaches in the human population, and some of these factors have b...

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Veröffentlicht in:	AIDS research and human retroviruses 1998-04, Vol.14 Suppl 1 (suppl. 1), p.S83-S87
Hauptverfasser:	Pauza, C D, Horejsh, D, Wallace, M
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Vaccines AIDS/HIV Animals Disease Models, Animal Disease Progression HIV Infections - transmission HIV-1 - pathogenicity Humans Macaca mulatta Mucous Membrane - virology Simian Acquired Immunodeficiency Syndrome - transmission Simian Immunodeficiency Virus - pathogenicity Virulence
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Beschreibung
Zusammenfassung:	Sexual transmission of human immunodeficiency virus provides an efficient mode for virus spread and poses unique challenges to vaccine developers. Host and viral factors that affect transmission have been studied by epidemiological approaches in the human population, and some of these factors have been modeled with experimental infection of nonhuman primates. Basic principles have emerged regarding transmission and viral virulence. These ideas may be beneficial for designing a safe and effective vaccine.
ISSN:	0889-2229