Amyloid β-protein precursor is associated with extracellular matrix
The ultrastructural distribution of the amyloid β-protein precursor (ABPP) in cultures of a neuronal cell line is examined. ABPP is associated with the extensive extracellular matrix (ECM) secreted by these cells. The possible role of matrix associated ABPP in the pathogenesis of Alzheimer's di...
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| Veröffentlicht in: | Brain research 1990-05, Vol.515 (1), p.336-342 |
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| container_title | Brain research |
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| creator | Klier, F.G. Cole, G. Stallcup, W. Schubert, D. |
| description | The ultrastructural distribution of the amyloid β-protein precursor (ABPP) in cultures of a neuronal cell line is examined. ABPP is associated with the extensive extracellular matrix (ECM) secreted by these cells. The possible role of matrix associated ABPP in the pathogenesis of Alzheimer's disease is discussed. |
| doi_str_mv | 10.1016/0006-8993(90)90619-M |
| format | Article |
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ABPP is associated with the extensive extracellular matrix (ECM) secreted by these cells. The possible role of matrix associated ABPP in the pathogenesis of Alzheimer's disease is discussed.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(90)90619-M</identifier><identifier>PMID: 2113416</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Amyloid - metabolism ; Amyloid beta-Protein Precursor ; Amyloid β-protein precursor ; Analytical, structural and metabolic biochemistry ; Animals ; Biological and medical sciences ; Cell Line ; Extracellular matrix ; Extracellular Matrix - metabolism ; Fundamental and applied biological sciences. 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ABPP is associated with the extensive extracellular matrix (ECM) secreted by these cells. The possible role of matrix associated ABPP in the pathogenesis of Alzheimer's disease is discussed.</description><subject>Amyloid - metabolism</subject><subject>Amyloid beta-Protein Precursor</subject><subject>Amyloid β-protein precursor</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Extracellular matrix</subject><subject>Extracellular Matrix - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Miscellaneous</subject><subject>Neurons - metabolism</subject><subject>Neurons - ultrastructure</subject><subject>NG2 proteoglycan</subject><subject>Protein Precursors - metabolism</subject><subject>Proteins</subject><subject>Rats</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctKxDAUhoMoOl7eQKEbRRfVk8ukyUYYxiuMuNF1SJMUI-10TFodX8sH8ZlsnaI7XYVwvvPz8x2E9jGcYsD8DAB4KqSkxxJOJHAs07s1NMIiIyknDNbR6AfZQtsxPndfSiVsok2CMWWYj9DFpHova2-Tz490EerG-XmyCM60IdYh8THRMdbG68bZ5M03T4lbNkEbV5ZtqUNS6Sb45S7aKHQZ3d7w7qDHq8uH6U06u7--nU5mqWFYNKnluYaCSKMJp2NprZaFgExQkrPcgiFcEitIxotxQXPjBNbjjGecAXWgM0J30NEqt2v60rrYqMrHvoueu7qNKpOCMZD8XxD3uRiLDmQr0IQ6xuAKtQi-0uFdYVC9ZdUrVL1CJUF9W1Z33drBkN_mlbM_S4PWbn44zHU0uiyCnhsff7MlkZBh1nHnK8511l69Cyoa7-bGWd_doFG29n8X-QJBzZlG</recordid><startdate>19900507</startdate><enddate>19900507</enddate><creator>Klier, F.G.</creator><creator>Cole, G.</creator><creator>Stallcup, W.</creator><creator>Schubert, D.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19900507</creationdate><title>Amyloid β-protein precursor is associated with extracellular matrix</title><author>Klier, F.G. ; Cole, G. ; Stallcup, W. ; Schubert, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-d6ba0f29ca26359dda9f807832b4bd0c2692d8276f5f3bce81a57676403e0a723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Amyloid - metabolism</topic><topic>Amyloid beta-Protein Precursor</topic><topic>Amyloid β-protein precursor</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Extracellular matrix</topic><topic>Extracellular Matrix - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Miscellaneous</topic><topic>Neurons - metabolism</topic><topic>Neurons - ultrastructure</topic><topic>NG2 proteoglycan</topic><topic>Protein Precursors - metabolism</topic><topic>Proteins</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klier, F.G.</creatorcontrib><creatorcontrib>Cole, G.</creatorcontrib><creatorcontrib>Stallcup, W.</creatorcontrib><creatorcontrib>Schubert, D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klier, F.G.</au><au>Cole, G.</au><au>Stallcup, W.</au><au>Schubert, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amyloid β-protein precursor is associated with extracellular matrix</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1990-05-07</date><risdate>1990</risdate><volume>515</volume><issue>1</issue><spage>336</spage><epage>342</epage><pages>336-342</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The ultrastructural distribution of the amyloid β-protein precursor (ABPP) in cultures of a neuronal cell line is examined. ABPP is associated with the extensive extracellular matrix (ECM) secreted by these cells. The possible role of matrix associated ABPP in the pathogenesis of Alzheimer's disease is discussed.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2113416</pmid><doi>10.1016/0006-8993(90)90619-M</doi><tpages>7</tpages></addata></record> |
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| ispartof | Brain research, 1990-05, Vol.515 (1), p.336-342 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amyloid - metabolism Amyloid beta-Protein Precursor Amyloid β-protein precursor Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cell Line Extracellular matrix Extracellular Matrix - metabolism Fundamental and applied biological sciences. Psychology Miscellaneous Neurons - metabolism Neurons - ultrastructure NG2 proteoglycan Protein Precursors - metabolism Proteins Rats |
| title | Amyloid β-protein precursor is associated with extracellular matrix |
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