Amyloid β-protein precursor is associated with extracellular matrix

The ultrastructural distribution of the amyloid β-protein precursor (ABPP) in cultures of a neuronal cell line is examined. ABPP is associated with the extensive extracellular matrix (ECM) secreted by these cells. The possible role of matrix associated ABPP in the pathogenesis of Alzheimer's di...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research 1990-05, Vol.515 (1), p.336-342
Hauptverfasser:	Klier, F.G., Cole, G., Stallcup, W., Schubert, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid - metabolism Amyloid beta-Protein Precursor Amyloid β-protein precursor Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cell Line Extracellular matrix Extracellular Matrix - metabolism Fundamental and applied biological sciences. Psychology Miscellaneous Neurons - metabolism Neurons - ultrastructure NG2 proteoglycan Protein Precursors - metabolism Proteins Rats
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The ultrastructural distribution of the amyloid β-protein precursor (ABPP) in cultures of a neuronal cell line is examined. ABPP is associated with the extensive extracellular matrix (ECM) secreted by these cells. The possible role of matrix associated ABPP in the pathogenesis of Alzheimer's disease is discussed.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(90)90619-M