Trisomy 12 is seen within a specific subtype of B‐cell chronic lymphoproliferative disease affecting the peripheral blood/bone marrow and co‐segregates with elevated expression of CD11a
In order to delineate the specific morphological and immunophenotypic features of B‐cell lymphoproliferative disorders associated with trisomy 12, 172 sequential unselected cases of CD19+CD5+ B‐cell disorders, primarily affecting the peripheral blood and bone marrow, were studied. Trisomy 12 was fou...
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| Veröffentlicht in: | British journal of haematology 1998-04, Vol.101 (1), p.165-170 |
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| creator | SU'UT, L O'CONNOR, S. J. M RICHARDS, S. J JONES, R. A ROBERTS, B. E DAVIES, F. E FEGAN, C. D JACK, A. S MORGAN, G. J |
| description | In order to delineate the specific morphological and immunophenotypic features of B‐cell lymphoproliferative disorders associated with trisomy 12, 172 sequential unselected cases of CD19+CD5+ B‐cell disorders, primarily affecting the peripheral blood and bone marrow, were studied. Trisomy 12 was found in 24 cases (13.9%), with all cases morphologically classified as either CLL‐PL or CLL‐mixed by FAB criteria. Trisomy 12 was not found in any cases of typical CLL. Trisomy 12 cases demonstrated a significant higher expression of CD11a (P |
| doi_str_mv | 10.1046/j.1365-2141.1998.00661.x |
| format | Article |
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With the highly specific morphological and immunophenotypic features demonstrated by trisomy 12 cases in this study, it is highly likely that these cases constitute a specific group of B‐cell lymphoproliferative disorders.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.1365-2141.1998.00661.x</identifier><identifier>PMID: 9576197</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, U.K. and Cambridge, USA: Blackwell Publishers</publisher><subject>Adult ; Aged ; Aged, 80 and over ; atypical CLL ; B-Lymphocytes - metabolism ; B-Lymphocytes - pathology ; Biological and medical sciences ; Bone Marrow Cells - pathology ; Chromosomes, Human, Pair 12 - genetics ; CLL ; Female ; Hematologic and hematopoietic diseases ; Hematology ; Humans ; Immunophenotyping ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphocyte Function-Associated Antigen-1 - metabolism ; lymphoproliferative disease ; Lymphoproliferative Disorders - genetics ; Lymphoproliferative Disorders - metabolism ; Male ; Medical sciences ; Middle Aged ; progression ; Trisomy ; trisomy 12</subject><ispartof>British journal of haematology, 1998-04, Vol.101 (1), p.165-170</ispartof><rights>1998 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Apr 1998</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4691-16a21b1c7bd71fffed577f24fc65e93b57c1107553c8d34818305c2a2feb06483</citedby><cites>FETCH-LOGICAL-c4691-16a21b1c7bd71fffed577f24fc65e93b57c1107553c8d34818305c2a2feb06483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2141.1998.00661.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2141.1998.00661.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,1434,27929,27930,45579,45580,46414,46838</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2201616$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9576197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SU'UT, L</creatorcontrib><creatorcontrib>O'CONNOR, S. J. M</creatorcontrib><creatorcontrib>RICHARDS, S. J</creatorcontrib><creatorcontrib>JONES, R. A</creatorcontrib><creatorcontrib>ROBERTS, B. E</creatorcontrib><creatorcontrib>DAVIES, F. E</creatorcontrib><creatorcontrib>FEGAN, C. D</creatorcontrib><creatorcontrib>JACK, A. S</creatorcontrib><creatorcontrib>MORGAN, G. J</creatorcontrib><title>Trisomy 12 is seen within a specific subtype of B‐cell chronic lymphoproliferative disease affecting the peripheral blood/bone marrow and co‐segregates with elevated expression of CD11a</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>In order to delineate the specific morphological and immunophenotypic features of B‐cell lymphoproliferative disorders associated with trisomy 12, 172 sequential unselected cases of CD19+CD5+ B‐cell disorders, primarily affecting the peripheral blood and bone marrow, were studied. Trisomy 12 was found in 24 cases (13.9%), with all cases morphologically classified as either CLL‐PL or CLL‐mixed by FAB criteria. Trisomy 12 was not found in any cases of typical CLL. Trisomy 12 cases demonstrated a significant higher expression of CD11a (P<0.0001) and CD20 (P<0.0006) when compared to cases with the equivalent morphology and immunophenotype, but without the chromosomal abnormality. Trisomy 12 cases also demonstrated a higher frequency of FMC7, CD38 expression and moderate to strong surface immunoglobulin staining. However, no correlation was detected between the percentages of trisomy 12 cells and cells expressing CD11a, CD38, FMC7 or sIg mean fluorescent intensity. Cells from trisomy 12 positive cases were sorted according to their CD11a expression using fluorescent activated cell sorting. There was a significant increase in the percentage of trisomy 12 cells within the CD11a+ sorted fraction compared to the unsorted population (P<0.05), implying that trisomy 12 is associated with increased expression of CD11a.
With the highly specific morphological and immunophenotypic features demonstrated by trisomy 12 cases in this study, it is highly likely that these cases constitute a specific group of B‐cell lymphoproliferative disorders.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>atypical CLL</subject><subject>B-Lymphocytes - metabolism</subject><subject>B-Lymphocytes - pathology</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Cells - pathology</subject><subject>Chromosomes, Human, Pair 12 - genetics</subject><subject>CLL</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphocyte Function-Associated Antigen-1 - metabolism</subject><subject>lymphoproliferative disease</subject><subject>Lymphoproliferative Disorders - genetics</subject><subject>Lymphoproliferative Disorders - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>progression</subject><subject>Trisomy</subject><subject>trisomy 12</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc2O0zAUhSMEGsrAIyBZCM0uHd_8OInEhik_AxqJzbC2HOe6cZXGwTeZtjsegRfiZXgSnGnVBStWjnW-e3xyTxQx4EvgmbjeLCEVeZxABkuoqnLJuRCw3D-JFmfhabTgnBdxGCifRy-INpxDynO4iC6qvBBQFYvo97235LYHBgmzxAixZzs7trZnitGA2hqrGU31eBiQOcNu_vz8pbHrmG6964PWHbZD6wbvOmvQq9E-IGssoSJkyhjUo-3XbGyRDejt0AamY3XnXHNdux7ZVnnvdkz1DdMumBOuPa7ViPQYhGGHD-HWMNwPHoms6-ccqw8A6mX0zKiO8NXpvIy-f_p4v7qN7759_rJ6fxfrTFQQg1AJ1KCLuinAhExNXhQmyYwWOVZpnRcagBd5nuqySbMSyrAmnajEYM1FVqaX0dXRN_zmjwlplFtL8xZUj24iWVRlxoNnAN_8A27c5PuQTUJVCuB5kgeoPELaOyKPRg7ehjUcJHA51ys3cm5Rzi3KuV75WK_ch9HXJ_-p3mJzHjz1GfS3J12RVp3xqteWzliScBAgAvbuiO1sh4f_fl7efL0NH-lfm3HExQ</recordid><startdate>199804</startdate><enddate>199804</enddate><creator>SU'UT, L</creator><creator>O'CONNOR, S. J. M</creator><creator>RICHARDS, S. J</creator><creator>JONES, R. A</creator><creator>ROBERTS, B. E</creator><creator>DAVIES, F. E</creator><creator>FEGAN, C. D</creator><creator>JACK, A. S</creator><creator>MORGAN, G. J</creator><general>Blackwell Publishers</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199804</creationdate><title>Trisomy 12 is seen within a specific subtype of B‐cell chronic lymphoproliferative disease affecting the peripheral blood/bone marrow and co‐segregates with elevated expression of CD11a</title><author>SU'UT, L ; O'CONNOR, S. J. M ; RICHARDS, S. J ; JONES, R. A ; ROBERTS, B. E ; DAVIES, F. E ; FEGAN, C. D ; JACK, A. S ; MORGAN, G. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4691-16a21b1c7bd71fffed577f24fc65e93b57c1107553c8d34818305c2a2feb06483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>atypical CLL</topic><topic>B-Lymphocytes - metabolism</topic><topic>B-Lymphocytes - pathology</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Cells - pathology</topic><topic>Chromosomes, Human, Pair 12 - genetics</topic><topic>CLL</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphocyte Function-Associated Antigen-1 - metabolism</topic><topic>lymphoproliferative disease</topic><topic>Lymphoproliferative Disorders - genetics</topic><topic>Lymphoproliferative Disorders - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>progression</topic><topic>Trisomy</topic><topic>trisomy 12</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SU'UT, L</creatorcontrib><creatorcontrib>O'CONNOR, S. J. M</creatorcontrib><creatorcontrib>RICHARDS, S. J</creatorcontrib><creatorcontrib>JONES, R. A</creatorcontrib><creatorcontrib>ROBERTS, B. E</creatorcontrib><creatorcontrib>DAVIES, F. E</creatorcontrib><creatorcontrib>FEGAN, C. D</creatorcontrib><creatorcontrib>JACK, A. S</creatorcontrib><creatorcontrib>MORGAN, G. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SU'UT, L</au><au>O'CONNOR, S. J. M</au><au>RICHARDS, S. J</au><au>JONES, R. A</au><au>ROBERTS, B. E</au><au>DAVIES, F. E</au><au>FEGAN, C. D</au><au>JACK, A. S</au><au>MORGAN, G. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trisomy 12 is seen within a specific subtype of B‐cell chronic lymphoproliferative disease affecting the peripheral blood/bone marrow and co‐segregates with elevated expression of CD11a</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>1998-04</date><risdate>1998</risdate><volume>101</volume><issue>1</issue><spage>165</spage><epage>170</epage><pages>165-170</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>In order to delineate the specific morphological and immunophenotypic features of B‐cell lymphoproliferative disorders associated with trisomy 12, 172 sequential unselected cases of CD19+CD5+ B‐cell disorders, primarily affecting the peripheral blood and bone marrow, were studied. Trisomy 12 was found in 24 cases (13.9%), with all cases morphologically classified as either CLL‐PL or CLL‐mixed by FAB criteria. Trisomy 12 was not found in any cases of typical CLL. Trisomy 12 cases demonstrated a significant higher expression of CD11a (P<0.0001) and CD20 (P<0.0006) when compared to cases with the equivalent morphology and immunophenotype, but without the chromosomal abnormality. Trisomy 12 cases also demonstrated a higher frequency of FMC7, CD38 expression and moderate to strong surface immunoglobulin staining. However, no correlation was detected between the percentages of trisomy 12 cells and cells expressing CD11a, CD38, FMC7 or sIg mean fluorescent intensity. Cells from trisomy 12 positive cases were sorted according to their CD11a expression using fluorescent activated cell sorting. There was a significant increase in the percentage of trisomy 12 cells within the CD11a+ sorted fraction compared to the unsorted population (P<0.05), implying that trisomy 12 is associated with increased expression of CD11a.
With the highly specific morphological and immunophenotypic features demonstrated by trisomy 12 cases in this study, it is highly likely that these cases constitute a specific group of B‐cell lymphoproliferative disorders.</abstract><cop>Oxford, U.K. and Cambridge, USA</cop><pub>Blackwell Publishers</pub><pmid>9576197</pmid><doi>10.1046/j.1365-2141.1998.00661.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0007-1048 |
| ispartof | British journal of haematology, 1998-04, Vol.101 (1), p.165-170 |
| issn | 0007-1048 1365-2141 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79840577 |
| source | MEDLINE; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection) |
| subjects | Adult Aged Aged, 80 and over atypical CLL B-Lymphocytes - metabolism B-Lymphocytes - pathology Biological and medical sciences Bone Marrow Cells - pathology Chromosomes, Human, Pair 12 - genetics CLL Female Hematologic and hematopoietic diseases Hematology Humans Immunophenotyping Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocyte Function-Associated Antigen-1 - metabolism lymphoproliferative disease Lymphoproliferative Disorders - genetics Lymphoproliferative Disorders - metabolism Male Medical sciences Middle Aged progression Trisomy trisomy 12 |
| title | Trisomy 12 is seen within a specific subtype of B‐cell chronic lymphoproliferative disease affecting the peripheral blood/bone marrow and co‐segregates with elevated expression of CD11a |
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