Trisomy 12 is seen within a specific subtype of B‐cell chronic lymphoproliferative disease affecting the peripheral blood/bone marrow and co‐segregates with elevated expression of CD11a

In order to delineate the specific morphological and immunophenotypic features of B‐cell lymphoproliferative disorders associated with trisomy 12, 172 sequential unselected cases of CD19+CD5+ B‐cell disorders, primarily affecting the peripheral blood and bone marrow, were studied. Trisomy 12 was fou...

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Veröffentlicht in:	British journal of haematology 1998-04, Vol.101 (1), p.165-170
Hauptverfasser:	SU'UT, L, O'CONNOR, S. J. M, RICHARDS, S. J, JONES, R. A, ROBERTS, B. E, DAVIES, F. E, FEGAN, C. D, JACK, A. S, MORGAN, G. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over atypical CLL B-Lymphocytes - metabolism B-Lymphocytes - pathology Biological and medical sciences Bone Marrow Cells - pathology Chromosomes, Human, Pair 12 - genetics CLL Female Hematologic and hematopoietic diseases Hematology Humans Immunophenotyping Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocyte Function-Associated Antigen-1 - metabolism lymphoproliferative disease Lymphoproliferative Disorders - genetics Lymphoproliferative Disorders - metabolism Male Medical sciences Middle Aged progression Trisomy trisomy 12
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Zusammenfassung:	In order to delineate the specific morphological and immunophenotypic features of B‐cell lymphoproliferative disorders associated with trisomy 12, 172 sequential unselected cases of CD19+CD5+ B‐cell disorders, primarily affecting the peripheral blood and bone marrow, were studied. Trisomy 12 was found in 24 cases (13.9%), with all cases morphologically classified as either CLL‐PL or CLL‐mixed by FAB criteria. Trisomy 12 was not found in any cases of typical CLL. Trisomy 12 cases demonstrated a significant higher expression of CD11a (P
ISSN:	0007-1048 1365-2141
DOI:	10.1046/j.1365-2141.1998.00661.x