Mitotane (o,p'-DDD) resistance in a dog with pituitary-dependent hyperadrenocorticism and phaeochromocytoma

A dog was presented with a 2 year history of polyuria and polydipsia due to pituitary‐dependent hyperadrenocorticism. A low‐dose dexamethasone suppression test and measurement of plasma ACTH concentration confirmed the diagnosis. Treatment was instituted with mitotane at 44 mg/kg/day and then 88 mg/...

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Veröffentlicht in:	Australian veterinary journal 1998-02, Vol.76 (2), p.101-103
Hauptverfasser:	Bennett, P.F, Norman, E.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Function Tests - veterinary Adrenal Gland Neoplasms - complications Adrenal Gland Neoplasms - drug therapy Adrenal Gland Neoplasms - veterinary adrenal medulla Adrenal Medulla - pathology Adrenocortical Hyperfunction - drug therapy Adrenocortical Hyperfunction - etiology Adrenocortical Hyperfunction - veterinary Animals Antineoplastic Agents, Hormonal - therapeutic use case studies Cushing syndrome dog Dog Diseases - drug therapy Dog Diseases - etiology Dog Diseases - metabolism Dogs drug resistance Drug Resistance, Neoplasm drug therapy Euthanasia - veterinary Female Liver Neoplasms - secondary Liver Neoplasms - veterinary mitotane Mitotane - therapeutic use neoplasms phaeochromocytoma Pheochromocytoma - complications Pheochromocytoma - drug therapy Pheochromocytoma - secondary Pheochromocytoma - veterinary Pituitary Diseases - complications Pituitary Diseases - drug therapy Pituitary Diseases - veterinary Pituitary-dependent hyperadrenocorticism
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Beschreibung
Zusammenfassung:	A dog was presented with a 2 year history of polyuria and polydipsia due to pituitary‐dependent hyperadrenocorticism. A low‐dose dexamethasone suppression test and measurement of plasma ACTH concentration confirmed the diagnosis. Treatment was instituted with mitotane at 44 mg/kg/day and then 88 mg/kg/d without complete resolution of signs. The dog collapsed with signs consistent with liver disease and was euthanased. Necropsy revealed a phaeochromocytoma of the left adrenal medulla with extensive metastases to the liver. A chromophobe adenoma of the pars intermedia of the pituitary was found.
ISSN:	0005-0423 1751-0813
DOI:	10.1111/j.1751-0813.1998.tb14536.x