Differences in plasma concentrations of the d- and l- threo methylphenidate enantiomers in responding and non-responding children with attention-deficit hyperactivity disorder

Differences in plasma concentrations of the d- and l- threo methylphenidate enantiomers in responding and non-responding children with attention-deficit hyperactivity disorder

Children with attention-deficit hyperactivity disorder who are categorized as responders or non-responders to methylphenidate (MPH) on the basis of their electrophysiological P3 response in a selective attention task differ in metabolic patterns of the d- and l- threo MPH enantiomers. Non-responders...

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Veröffentlicht in:Psychiatry research 1998-03, Vol.78 (1), p.115-118
Hauptverfasser: Jonkman, Lisa M., Verbaten, Marinus N., de Boer, D., Maes, R.A.A., Buitelaar, Jan K., Kemner, Chantal, van Engeland, Herman, Koelega, Harry S.
Format: Artikel
Sprache:eng
Schlagworte:
Analysis of Variance
Attention
Attention - drug effects
Attention - physiology
Attention Deficit Disorder with Hyperactivity - blood
Attention Deficit Disorder with Hyperactivity - classification
Attention Deficit Disorder with Hyperactivity - drug therapy
Attention Deficit Disorder with Hyperactivity - physiopathology
Biological and medical sciences
Central Nervous System Stimulants - blood
Central Nervous System Stimulants - chemistry
Central Nervous System Stimulants - pharmacokinetics
Child
Drug Resistance
Event-Related Potentials, P300 - drug effects
Event-Related Potentials, P300 - physiology
Evoked potentials
Female
Humans
Isomerism
Male
Medical sciences
Methylphenidate - blood
Methylphenidate - chemistry
Methylphenidate - pharmacokinetics
Neuropharmacology
P300
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Volition - drug effects
Volition - physiology
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Zusammenfassung:Children with attention-deficit hyperactivity disorder who are categorized as responders or non-responders to methylphenidate (MPH) on the basis of their electrophysiological P3 response in a selective attention task differ in metabolic patterns of the d- and l- threo MPH enantiomers. Non-responders showed significantly higher plasma concentrations of both d- and l- threo MPH enantiomers.
ISSN:0165-1781
1872-7123
DOI:10.1016/S0165-1781(97)00138-8