Vascular remodeling and growth factor gene expression in the rat lung during hypoxia

Recent studies suggest that the vasoactive peptides endothelin-1 and -3 and the mitogens VEGF and PDGF-A and -B could be involved in the pathogenesis of hypoxic pulmonary hypertension. We were interested to investigate whether these peptides could also be involved in the vascular remodeling occurrin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Respiration physiology 1998-02, Vol.111 (2), p.201-212
Hauptverfasser:	Pfeifer, Michael, Blumberg, Friedrich C, Wolf, Konrad, Sandner, Peter, Elsner, Dietmar, Riegger, Günther A.J, Kurtz, Armin
Format:	Artikel
Sprache:	eng
Schlagworte:	Air breathing Animals Biological and medical sciences Endothelial Growth Factors - genetics Endothelin-1 - genetics Endothelin-3 - genetics Fundamental and applied biological sciences. Psychology Gene Expression Growth Substances - genetics Hypertension, Pulmonary - etiology Hypoxia - complications Hypoxia - genetics Hypoxia - pathology Hypoxia, chronic, lung vascular remodeling Lung - blood supply Lung - metabolism Lymphokines - genetics Male Mammals, rat Mitogens, PDGF, VEGF Peptides, vasoactive, endothelin Platelet-Derived Growth Factor - genetics Pulmonary Circulation Pulmonary circulation, chronic hypoxia, vascular remodeling Rats Rats, Wistar Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics RNA, Messenger - genetics RNA, Messenger - metabolism Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Vertebrates: respiratory system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Recent studies suggest that the vasoactive peptides endothelin-1 and -3 and the mitogens VEGF and PDGF-A and -B could be involved in the pathogenesis of hypoxic pulmonary hypertension. We were interested to investigate whether these peptides could also be involved in the vascular remodeling occurring during chronic hypoxia (10% oxygen; 1 and 3 weeks) in the rat. Hypoxia increased significantly systolic right ventricular pressure and typical morphological signs of vascular remodeling were found. This was accompanied by increased ET-1 and the ET-3 mRNA expression after acute (6 h; P
ISSN:	0034-5687
DOI:	10.1016/S0034-5687(97)00102-3